INT132435

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Context Info
Confidence 0.50
First Reported 2005
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 3.75
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (ADAM17) cell motility (ADAM17) cell adhesion (ADAM17)
plasma membrane (ADAM17) cytoplasm (ADAM17)
ADAM17 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 1 99.28 Very High Very High Very High
Infliximab 1 96.76 Very High Very High Very High
Etanercept 1 95.84 Very High Very High Very High
antagonist 1 94.16 High High
anakinra 1 93.72 High High
Inflammation 3 90.68 High High
Crohn's disease 1 89.48 High High
rheumatoid arthritis 2 88.80 High High
spinal inflammation 1 87.92 High High
Arthritis 1 85.32 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 4 99.08 Very High Very High Very High
Pancreatic Cancer 6 98.36 Very High Very High Very High
Adenocarcinoma 12 92.80 High High
Disease 3 90.16 High High
Rheumatoid Arthritis 2 88.80 High High
Low Back Pain 1 87.92 High High
Cancer 9 87.80 High High
Seronegative Spondarthritis 1 85.72 High High
Psoriasis 1 84.76 Quite High
Hypersensitivity 1 80.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibitors of TACE and Caspase-1 as anti-inflammatory drugs.
Negative_regulation (Inhibitors) of TACE associated with inflammation and cinod
1) Confidence 0.50 Published 2005 Journal Curr. Med. Chem. Section Title Doc Link 16378499 Disease Relevance 1.16 Pain Relevance 0.74
The proteolytic activity of ADAM17/TACE, assessed by the release of TNF-alpha, was inhibited by TNF-alpha protease inhibitor.
Negative_regulation (inhibited) of ADAM17
2) Confidence 0.41 Published 2006 Journal Cancer Res. Section Abstract Doc Link 16982746 Disease Relevance 1.29 Pain Relevance 0.14
The proteolytic activity of ADAM17/TACE, assessed by the release of TNF-alpha, was inhibited by TNF-alpha protease inhibitor.
Negative_regulation (inhibited) of TACE
3) Confidence 0.18 Published 2006 Journal Cancer Res. Section Abstract Doc Link 16982746 Disease Relevance 1.29 Pain Relevance 0.14

General Comments

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