INT13244

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.31
First Reported 1981
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 30
Total Number 31
Disease Relevance 4.56
Pain Relevance 18.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Helt) nucleus (Helt) DNA binding (Helt)
Anatomy Link Frequency
ACC neurons 2
neurons 2
synapse 2
dorsal 1
striatum 1
Helt (Mus musculus)
Pain Link Frequency Relevance Heat
GABAergic 122 100.00 Very High Very High Very High
Anterior cingulate cortex 128 99.98 Very High Very High Very High
opiate 7 99.98 Very High Very High Very High
Opioid 7 99.80 Very High Very High Very High
anticonvulsant 1 99.76 Very High Very High Very High
Gabapentin 1 99.38 Very High Very High Very High
analgesia 3 99.36 Very High Very High Very High
Neurotransmitter 12 99.20 Very High Very High Very High
Pain 17 99.18 Very High Very High Very High
Analgesic 11 99.18 Very High Very High Very High
Disease Link Frequency Relevance Heat
Sleep Disorders 41 99.60 Very High Very High Very High
Anxiety Disorder 17 99.56 Very High Very High Very High
Targeted Disruption 61 96.40 Very High Very High Very High
Aids-related Complex 5 96.24 Very High Very High Very High
Psychosis 5 94.72 High High
Sprains And Strains 64 92.64 High High
Ganglion Cysts 4 92.48 High High
Pain 12 92.08 High High
Catalepsy 2 91.56 High High
Schizophrenia 2 90.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results suggest that naloxone and naltrexone may influence memory consolidation in CD1 mice by interacting with the GABAergic system.
GABAergic Binding (interacting) of associated with gabaergic and narcan
1) Confidence 0.31 Published 1989 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 2727018 Disease Relevance 0 Pain Relevance 0.59
Filicene obtained from Adiantum cuneatum interacts with the cholinergic, dopaminergic, glutamatergic, GABAergic, and tachykinergic systems to exert antinociceptive effect in mice.
GABAergic Binding (interacts) of associated with analgesic, gabaergic and antinociceptive
2) Confidence 0.31 Published 2009 Journal Pharmacol. Biochem. Behav. Section Title Doc Link 19375449 Disease Relevance 0.16 Pain Relevance 1.48
Together, these results indicate that the mechanisms involved in its action are not completely understood, but seem to involve interaction with the cholinergic, dopaminergic, glutamatergic, GABAergic and tachykinergic systems.
GABAergic Binding (interaction) of associated with gabaergic
3) Confidence 0.31 Published 2009 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 19375449 Disease Relevance 0.14 Pain Relevance 0.88
The mechanism of action is not completely understood, but seems to involve direct interaction with the GABAergic and nitroxidergic pathways.
GABAergic Binding (interaction) of associated with gabaergic
4) Confidence 0.31 Published 2007 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 17976270 Disease Relevance 0.23 Pain Relevance 0.57
One of the possible mechanisms of action for melatonin in the brain is the interaction with the GABAergic system, as suggested by neurochemical and behavioral data.
GABAergic Binding (interaction) of in brain associated with gabaergic
5) Confidence 0.21 Published 1996 Journal Neurosci Biobehav Rev Section Abstract Doc Link 8880732 Disease Relevance 0.26 Pain Relevance 0.17
Other ligands, such as flunitrazepam and quinuclidinyl benzilate that bind to GABAergic and cholinergic receptors, were visually less discriminating both among layers and between regions.
GABAergic Binding (bind) of associated with gabaergic
6) Confidence 0.21 Published 1988 Journal J. Neurosci. Section Abstract Doc Link 2848104 Disease Relevance 0 Pain Relevance 0.42
Morphine and opiates are known to exert anxiolytic effects, probably by interacting with the GABAergic system.
GABAergic Binding (interacting) of associated with gabaergic, anxiety disorder, opiate and morphine
7) Confidence 0.05 Published 2006 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 16626794 Disease Relevance 0.40 Pain Relevance 0.73
The lateral septum (LS), mainly constituted of GABA neurons, exhibits high densities of mu-opiate receptors and could thus represent one the brain sites where opiates interact with GABAergic transmission to modulate anxiety.
GABAergic Binding (interact) of in lateral associated with gaba, gabaergic, anxiety disorder and opiate
8) Confidence 0.05 Published 2006 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 16626794 Disease Relevance 0.44 Pain Relevance 0.86
In previous studies we have demonstrated a possible interaction between the GABAergic and opioid systems involved in the antinociceptive effect of the GABA(B) agonist, baclofen (BAC).
GABAergic Binding (interaction) of associated with gaba, gabaergic, agonist, antinociceptive and opioid
9) Confidence 0.04 Published 2001 Journal Behav Pharmacol Section Abstract Doc Link 11270515 Disease Relevance 0.15 Pain Relevance 0.86
However, interactions between the cholinergic and GABAergic systems have been previously described.
GABAergic Binding (interactions) of associated with gabaergic
10) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816210 Disease Relevance 0.09 Pain Relevance 0.21
Although it is likely that GABAergic synapse kinetics can account for the observed variation in oscillation frequency between mouse lines, there might be other genes that contribute to differences in properties of fast network oscillations in these strains.
GABAergic Binding (account) of in synapse associated with gabaergic and sprains and strains
11) Confidence 0.03 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2901093 Disease Relevance 0.15 Pain Relevance 0.40
Thus, we propose that the state of activation of vagal sensory inputs determines the gastric motor response via selective engagement of GABAergic synapses.
GABAergic Binding (engagement) of in synapses associated with gabaergic
12) Confidence 0.03 Published 2006 Journal Auton Neurosci Section Abstract Doc Link 16580267 Disease Relevance 0 Pain Relevance 0.42
WT and PrP-null mouse neurons both expressed NR2D subunit mRNA and protein, with ?
neurons Binding (null) of in neurons
13) Confidence 0.02 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0 Pain Relevance 0.04
Higher environmental temperature-induced increase of body temperature: involvement of central opioidergic-GABAergic interaction.
GABAergic Binding (interaction) of in body associated with gabaergic
14) Confidence 0.01 Published 1995 Journal Pharmacol. Biochem. Behav. Section Title Doc Link 7501682 Disease Relevance 0.13 Pain Relevance 0.40
These findings suggest that the potentiation of pilocarpine-induced analgesia by muscimol is unrelated to an interaction of the GABAergic system with the striatal cholinergic or dopaminergic systems.
GABAergic Binding (interaction) of associated with gabaergic and analgesia
15) Confidence 0.01 Published 1981 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 6794090 Disease Relevance 0.17 Pain Relevance 0.43
To substantiate this finding, we further examined the association of GABAergic synaptic markers with BG fibers.
GABAergic Spec (examined) Binding (association) of associated with gabaergic
16) Confidence 0.01 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2689695 Disease Relevance 0 Pain Relevance 0.14
In humans, loss of HCRT neurons is associated with the sleep disorder narcolepsy and inappropriate triggering of REM sleep [1], [2].
neurons Binding (associated) of in neurons associated with sleep disorders
17) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.45 Pain Relevance 0.07
However, the neurobiological basis of how the ACC neurons are activated and engaged in sexual attraction remains poorly understood.
neurons Binding (engaged) of in ACC neurons associated with anterior cingulate cortex
18) Confidence 0.01 Published 2009 Journal Mol Brain Section Body Doc Link PMC2685783 Disease Relevance 0.32 Pain Relevance 0.59
However, the neurobiological basis of how the ACC neurons are activated and engaged in sexual attraction remains unknown.
neurons Binding (engaged) of in ACC neurons associated with anterior cingulate cortex
19) Confidence 0.01 Published 2009 Journal Mol Brain Section Abstract Doc Link PMC2685783 Disease Relevance 0.10 Pain Relevance 0.49
Presented results are discussed in light of interactions between enkephalinergic, GABAergic, and dopaminergic systems in the striatum and mesolimbic areas of the brain.


GABAergic Binding (interactions) of in striatum
20) Confidence 0.00 Published 2007 Journal Psychopharmacology (Berl.) Section Body Doc Link 17497229 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox