INT132445

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Context Info
Confidence 0.11
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 2.23
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (TF, IL8) signal transduction (IL8) extracellular space (IL8)
mitochondrion (TF) intracellular (IL8) cytoplasmic membrane-bounded vesicle (TF)
Anatomy Link Frequency
umbilical vein 2
TF (Homo sapiens)
IL8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 10 90.24 High High
Angina 2 71.88 Quite High
Disease Link Frequency Relevance Heat
Endotoxemia 2 96.76 Very High Very High Very High
Thrombosis 8 92.52 High High
Increased Venous Pressure Under Development 2 87.20 High High
Sepsis 2 86.40 High High
INFLAMMATION 8 85.24 High High
Disseminated Intravascular Coagulation 4 73.88 Quite High
Cv General 3 Under Development 2 71.88 Quite High
Disease 2 70.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, in vitro studies indicate that BCX-3607 blocks the generation of TF/FVIIa-induced IL-8 mRNA in human keratinocytes and reduces the TF/FVIIa-mediated generation of IL-6 and IL-8 in human umbilical vein endothelial cells (HUVEC).
TF Positive_regulation (induced) of IL-8 in umbilical vein
1) Confidence 0.11 Published 2006 Journal Thromb. Res. Section Abstract Doc Link 16378835 Disease Relevance 1.13 Pain Relevance 0.23
Additionally, in vitro studies indicate that BCX-3607 blocks the generation of TF/FVIIa-induced IL-8 mRNA in human keratinocytes and reduces the TF/FVIIa-mediated generation of IL-6 and IL-8 in human umbilical vein endothelial cells (HUVEC).
TF Positive_regulation (generation) of IL-8 in umbilical vein
2) Confidence 0.05 Published 2006 Journal Thromb. Res. Section Abstract Doc Link 16378835 Disease Relevance 1.10 Pain Relevance 0.23

General Comments

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