INT13245

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Context Info
Confidence 0.33
First Reported 1990
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 0.87
Pain Relevance 2.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gpr156) signal transducer activity (Gpr156)
Anatomy Link Frequency
hypothalamus 2
Gpr156 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 16 100.00 Very High Very High Very High
tetrodotoxin 13 99.76 Very High Very High Very High
mu opioid receptor 2 99.68 Very High Very High Very High
fluoxetine 1 99.32 Very High Very High Very High
Dopamine 73 98.60 Very High Very High Very High
GABAergic 23 98.04 Very High Very High Very High
Ventral tegmentum 69 97.52 Very High Very High Very High
Endep 2 97.20 Very High Very High Very High
Endogenous opioid 1 96.60 Very High Very High Very High
depression 5 96.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aids-related Complex 5 97.48 Very High Very High Very High
Depression 5 96.48 Very High Very High Very High
Urological Neuroanatomy 16 92.72 High High
Hypotension 1 66.76 Quite High
Bordatella Infection 1 53.04 Quite High
Decapitation 3 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Epilepsy 1 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The activation of GABAB receptors did not modulate postsynaptic GABAA receptor responses.
Neg (not) Regulation (modulate) of Positive_regulation (activation) of GABAB
1) Confidence 0.33 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9465016 Disease Relevance 0.15 Pain Relevance 0.60
Preincubation of GABAB receptor antagonist CGP55845 had no significant effect on evoked IPSPs from both pathways.
Neg (no) Regulation (effect) of Positive_regulation (Preincubation) of GABAB receptor associated with antagonist
2) Confidence 0.23 Published 2010 Journal Frontiers in Neurology Section Body Doc Link PMC3009458 Disease Relevance 0.25 Pain Relevance 0.40
This study examined the effects of selective activation of GABAB and/or mu-opioid receptors on neurons of the arcuate nucelus (ARC) of the rat hypothalamus using intracellular recording of cells in a hypothalamic slice.
Spec (examined) Regulation (effects) of Spec (examined) Positive_regulation (activation) of GABAB in hypothalamus associated with aids-related complex and mu opioid receptor
3) Confidence 0.22 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 1664497 Disease Relevance 0.23 Pain Relevance 0.36
However, to date, there is a lack of information regarding the effect of GABAB receptor activation on the release of somatodendritic dopamine from the isolated VTA.
Regulation (effect) of Positive_regulation (activation) of GABAB associated with ventral tegmentum and dopamine
4) Confidence 0.17 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC526276 Disease Relevance 0 Pain Relevance 0.72
GH response to acute GABAB receptor activation did not differ between depressed subjects and healthy controls.
Regulation (response) of Positive_regulation (activation) of GABAB receptor
5) Confidence 0.13 Published 1990 Journal J Affect Disord Section Abstract Doc Link 2174069 Disease Relevance 0.24 Pain Relevance 0.58

General Comments

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