INT132453

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Context Info
Confidence 0.36
First Reported 2006
Last Reported 2010
Negated 4
Speculated 1
Reported most in Body
Documents 31
Total Number 32
Disease Relevance 12.98
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (TF) extracellular region (TF) cytoplasmic membrane-bounded vesicle (TF)
transmembrane transport (TF)
Anatomy Link Frequency
plasma 3
bone marrow 2
liver 1
pancreas 1
vein 1
TF (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 15 96.48 Very High Very High Very High
cytokine 50 95.84 Very High Very High Very High
rheumatoid arthritis 52 92.72 High High
Inflammation 128 89.52 High High
visual analogue scale 3 87.52 High High
anesthesia 8 84.00 Quite High
ketamine 1 83.56 Quite High
Pain 16 70.84 Quite High
Ziconotide 3 67.88 Quite High
TRP channel 41 48.20 Quite Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 22 100.00 Very High Very High Very High
Myocardial Infarction 76 99.98 Very High Very High Very High
Intrauterine Growth Retardation 1 99.92 Very High Very High Very High
Vibrio Infection 6 99.64 Very High Very High Very High
Cancer 110 99.62 Very High Very High Very High
Apoptosis 82 99.34 Very High Very High Very High
Necrosis 19 98.88 Very High Very High Very High
Thrombophilia 6 97.88 Very High Very High Very High
Atherosclerotic Plaque 2 97.36 Very High Very High Very High
Syndrome 39 97.22 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The cells were then suspended in DMEM/F12 (Invitrogen, Carlsbad, CA) supplemented with 5 µg/ml insulin (Sigma), 50 µg/ml transferrin (Sigma), 30 nM selenium chloride (Sigma), and 5 µg/ml fibronectin (Sigma) (ITSFn medium), followed by magnetic separation of A2B5+ cells.
transferrin Binding (supplemented) of
1) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2866321 Disease Relevance 0 Pain Relevance 0.13
There is growing evidence that circulating TF is potentially active in an encrypted state, where it can bind FVII, but lacks proteolytic activity [31].
TF Neg (lacks) Binding (bind) of
2) Confidence 0.35 Published 2009 Journal Thromb J Section Body Doc Link PMC2714503 Disease Relevance 0.81 Pain Relevance 0.08
In AMI TF activity was associated with markers of myocardial necrosis.
TF Binding (associated) of associated with necrosis and myocardial infarction
3) Confidence 0.32 Published 2009 Journal Thromb J Section Body Doc Link PMC2714503 Disease Relevance 0.79 Pain Relevance 0.08
As such, the TF/FVIIa complex plays an important role in normal physiology as well as in thrombotic diseases such as unstable angina (UA), disseminated intravascular coagulation (DIC), and deep vein thrombosis (DVT).
TF Binding (complex) of in vein associated with angina, disseminated intravascular coagulation, disease and thrombosis
4) Confidence 0.31 Published 2006 Journal Thromb. Res. Section Abstract Doc Link 16378835 Disease Relevance 1.02 Pain Relevance 0.21
It forms a complex with transferrin before they are delivered into the cells via interactions with surface transferrin receptor (TfnR)[10].
transferrin Binding (interactions) of
5) Confidence 0.23 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2817924 Disease Relevance 0.45 Pain Relevance 0.13
It forms a complex with transferrin before they are delivered into the cells via interactions with surface transferrin receptor (TfnR)[10].
transferrin Binding (complex) of
6) Confidence 0.18 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2817924 Disease Relevance 0.44 Pain Relevance 0.14
HT29 cells were pre-treated with serial concentrations of geoditin A for 24 h, depleted endogenous transferrin by incubating in plain DMEM containing 1% BSA for 1 h before transferrin uptake assay was performed for 1 h in DMEM containing 50 ?
transferrin Binding (endogenous) of
7) Confidence 0.18 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2817924 Disease Relevance 0 Pain Relevance 0
In addition, there were no significant associations between serum iron, serum ferritin, or transferrin saturation and either ln(%B) or ln(%S) in multiple linear regression analyses that included ethnicity and type of oral hypoglycemic therapy as potential independent variables (P > 0.21).


transferrin Neg (no) Spec (analyses) Binding (associations) of
8) Confidence 0.17 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2518347 Disease Relevance 0.88 Pain Relevance 0
It could be argued that apotransferrin does not bind to transferrin receptors but would bind extracellular free iron, forming holo-transferrin, which would then be capable of binding to the transferrin receptor and internalize and actually increase cellular iron stores.
holo-transferrin Neg (not) Binding (bind) of
9) Confidence 0.10 Published 2008 Journal Diabetes Section Body Doc Link PMC2453621 Disease Relevance 0.29 Pain Relevance 0
The internalization of FITC-transferrin was severely impaired in cells expressing GFP-EPS?
FITC-transferrin Binding (internalization) of
10) Confidence 0.09 Published 2010 Journal Virol J Section Body Doc Link PMC2825209 Disease Relevance 0.15 Pain Relevance 0
Indeed, in ChIP-seq, the DNA fragments of interest (i.e., binding sites for a TF) are directly sequenced instead of being hybridized on a chip-array.
TF Binding (binding) of
11) Confidence 0.09 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943117 Disease Relevance 0.22 Pain Relevance 0
Serum pro-hepcidin concentration negatively correlated with serum iron (r=-0.23, P=0.04), but it did not correlate with TIBC, ferritin and transferrin.
transferrin Neg (not) Binding (correlate) of
12) Confidence 0.09 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2826733 Disease Relevance 0.93 Pain Relevance 0.25
Iron dextran (INFeD, DexFerrum), unlike ferric gluconate and iron sucrose, is higher in molecular weight and releases iron more slowly to be bound by transferrin and to supply the bone marrow.
transferrin Binding (bound) of in bone marrow
13) Confidence 0.09 Published 2010 Journal Dig Dis Sci Section Body Doc Link PMC2822907 Disease Relevance 1.09 Pain Relevance 0
Once transported across the duodenal luminal membrane, iron is carried across the cytoplasm by a carrier protein and is bound by transferrin at the basolateral membrane.
transferrin Binding (bound) of
14) Confidence 0.09 Published 2010 Journal Dig Dis Sci Section Body Doc Link PMC2822907 Disease Relevance 0.28 Pain Relevance 0
In the plasma, iron is usually bound by transferrin and is taken up by tissues expressing cell-surface transferrin receptors.
transferrin Binding (bound) of in plasma
15) Confidence 0.09 Published 2010 Journal Dig Dis Sci Section Body Doc Link PMC2822907 Disease Relevance 0.34 Pain Relevance 0
Incubation with human apolipoprotein–transferrin (10 ?
transferrin Binding (Incubation) of associated with disorder of lipid metabolism
16) Confidence 0.08 Published 2008 Journal Diabetes Section Body Doc Link PMC2453621 Disease Relevance 0.24 Pain Relevance 0
Flow cytometry measurements revealed that depletion of plasma membrane SM reduced VacA binding by more than 80% (Figure 3C and 3D), while not affecting the binding of transferrin (Tf) or the cholera toxin B fragment (CTB) (Figure 3D).
transferrin Binding (binding) of in plasma associated with vibrio infection
17) Confidence 0.08 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2374909 Disease Relevance 0.25 Pain Relevance 0
Flow cytometry measurements revealed that depletion of plasma membrane SM reduced VacA binding by more than 80% (Figure 3C and 3D), while not affecting the binding of transferrin (Tf) or the cholera toxin B fragment (CTB) (Figure 3D).
Tf Binding (binding) of in plasma associated with vibrio infection
18) Confidence 0.08 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2374909 Disease Relevance 0.25 Pain Relevance 0
TF binds to factor VIIa, resulting in a TF–factor VIIa complex, which is responsible for the conversion of factor X to factor Xa.
TF Binding (complex) of
19) Confidence 0.07 Published 2006 Journal Crit Care Section Body Doc Link PMC1550851 Disease Relevance 0.38 Pain Relevance 0.14
It could be argued that apotransferrin does not bind to transferrin receptors but would bind extracellular free iron, forming holo-transferrin, which would then be capable of binding to the transferrin receptor and internalize and actually increase cellular iron stores.
holo-transferrin Binding (binding) of
20) Confidence 0.07 Published 2008 Journal Diabetes Section Body Doc Link PMC2453621 Disease Relevance 0.29 Pain Relevance 0

General Comments

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