INT132495

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Context Info
Confidence 0.44
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.64
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ppard) lipid binding (Ppard) cell proliferation (Ppard)
nucleus (Ppard) DNA binding (Ppard) lipid metabolic process (Ppard)
Anatomy Link Frequency
SW480 2
Ppard (Mus musculus)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 1 99.98 Very High Very High Very High
cINOD 16 99.24 Very High Very High Very High
COX2 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Familial Adenomatous Polyposis 5 94.48 High High
Apoptosis 16 93.44 High High
Colon Cancer 12 75.60 Quite High
INFLAMMATION 6 75.28 Quite High
Cancer 1 69.84 Quite High
Death 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Sulindac sulfide inhibited PPARdelta protein expression and PPARdelta transcriptional activity.
Negative_regulation (inhibited) of Gene_expression (expression) of PPARdelta
1) Confidence 0.44 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17409426 Disease Relevance 0.77 Pain Relevance 0.46
Sulindac sulfide inhibited PPARdelta protein expression and PPARdelta transcriptional activity.
Negative_regulation (inhibited) of Gene_expression (expression) of PPARdelta
2) Confidence 0.32 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17409426 Disease Relevance 0.77 Pain Relevance 0.47
Furthermore, the COX-2 inhibitors suppress PPARdelta expression.
Negative_regulation (suppress) of Gene_expression (expression) of PPARdelta associated with cox-2 inhibitor
3) Confidence 0.29 Published 2009 Journal Methods Mol. Biol. Section Abstract Doc Link 19347284 Disease Relevance 0.60 Pain Relevance 0.28
Sulindac sulfone was consistently more potent than the sulfide metabolite in all analyses, significantly decreasing the expression of total cellular beta-catenin (50% of control), pro-caspase 3 (49%), cyclin D1 (51%), and PPARdelta (65%) in SW480 cells.
Negative_regulation (decreasing) of Gene_expression (expression) of PPARdelta in SW480
4) Confidence 0.06 Published 2005 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 16382042 Disease Relevance 0.51 Pain Relevance 0.08

General Comments

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