INT132498

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Context Info
Confidence 0.48
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
liver 1
Cyp2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antidepressant 7 99.98 Very High Very High Very High
sSRI 3 95.92 Very High Very High Very High
Endep 3 81.48 Quite High
Desipramine 3 75.88 Quite High
fluoxetine 3 75.24 Quite High
tricyclic antidepressant 1 40.40 Quite Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In summary, two different mechanisms of the antidepressant-CYP2A interaction have been found in rat liver: 1) the direct inhibition of CYP2A by most of the investigated TADs and SSRIs; 2) the in vivo weak induction of CYP2A by clomipramine and sertraline.
CYP2A Binding (interaction) of in liver associated with antidepressant and ssri
1) Confidence 0.48 Published 2005 Journal Pharmacol Rep Section Abstract Doc Link 16382196 Disease Relevance 0 Pain Relevance 0.56

General Comments

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