INT132503

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Context Info
Confidence 0.43
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
liver 2
Cyp2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
sSRI 3 100.00 Very High Very High Very High
antidepressant 7 98.74 Very High Very High Very High
Endep 3 79.00 Quite High
Desipramine 3 73.40 Quite High
fluoxetine 3 72.76 Quite High
tricyclic antidepressant 1 37.92 Quite Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In summary, two different mechanisms of the antidepressant-CYP2A interaction have been found in rat liver: 1) the direct inhibition of CYP2A by most of the investigated TADs and SSRIs; 2) the in vivo weak induction of CYP2A by clomipramine and sertraline.
Negative_regulation (inhibition) of Positive_regulation (induction) of CYP2A in liver associated with antidepressant and ssri
1) Confidence 0.43 Published 2005 Journal Pharmacol Rep Section Abstract Doc Link 16382196 Disease Relevance 0 Pain Relevance 0.55

General Comments

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