INT132512

Context Info Confidence 0.16 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.32 Pain Relevance 0.06

plasma membrane (RASGRP1, OPCML) cell differentiation (RASGRP1) Golgi apparatus (RASGRP1) endoplasmic reticulum (RASGRP1) cytoplasm (RASGRP1) cytosol (RASGRP1)

Anatomy Link Frequency T29H 1 RASGRP1 (Homo sapiens) OPCML (Homo sapiens)

Pain Link Frequency Relevance Heat Opioid 1 55.04

Disease Link Frequency Relevance Heat Ovarian Cancer 4 74.92 Cancer 1 58.48 Adhesions 1 56.24

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

Furthermore, suppression of oncogenic RAS activity by stable siRNA specific for HRAS(V12) led to the demethylation and re-expression of OPCML in T29H cells, demonstrating that oncogenic RAS activity is directly responsible for the observed OPCML promoter hypermethylation and epigenetic gene silencing of OPCML.

oncogenic RAS Regulation (responsible) of OPCML in T29H

1) Confidence 0.16 Published 2006 Journal FASEB J. Section Abstract Doc Link 16384911 Disease Relevance 0.32 Pain Relevance 0.06

General Comments

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