INT132514

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Context Info
Confidence 0.69
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 8
Disease Relevance 4.81
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (OPCML) plasma membrane (OPCML)
Anatomy Link Frequency
SW480 2
T29H 2
OPCML (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 15 63.72 Quite High
Disease Link Frequency Relevance Heat
Cancer 393 99.52 Very High Very High Very High
Stress 126 98.88 Very High Very High Very High
Shock 14 96.20 Very High Very High Very High
Carcinoma 91 94.48 High High
Lymphatic System Cancer 105 93.68 High High
Hodgkin's Disease 7 92.64 High High
Contagious Ecthyma 7 90.48 High High
Prostate Cancer 35 85.60 High High
Ovarian Cancer 32 83.60 Quite High
Nasopharynx Cancer 161 79.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that the expression of OPCML-v1 was dramatically elevated in cell lines with an unmethylated promoter, after exposure to various stresses, such as heat shock, UV irradiation and H2O2 treatment.
Positive_regulation (elevated) of Gene_expression (expression) of OPCML-v1 associated with stress and shock
1) Confidence 0.69 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500176 Disease Relevance 1.21 Pain Relevance 0
Pharmacological and genetic demethylation restored OPCML expression, indicating a direct epigenetic silencing.
Positive_regulation (restored) of Gene_expression (expression) of OPCML
2) Confidence 0.60 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2500176 Disease Relevance 1.45 Pain Relevance 0
Pharmacologic and genetic demethylation restored OPCML-v1 expression
Positive_regulation (restored) of Gene_expression (expression) of OPCML-v1
3) Confidence 0.60 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500176 Disease Relevance 0.75 Pain Relevance 0
Deletion analysis of OPCML by multiplex PCR
Positive_regulation (analysis) of Gene_expression (analysis) of OPCML
4) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500176 Disease Relevance 0.23 Pain Relevance 0
Silencing of OPCML by CpG methylation in tumor cell lines
Positive_regulation (Silencing) of Gene_expression (Silencing) of OPCML associated with cancer
5) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500176 Disease Relevance 0.46 Pain Relevance 0
Cells were then transiently transfected with 0.5 µg of pcDNA3.1+/OPCML-v1 or pcDNA 3.1 vector alone, using Fugene6.0 (Roche, Switzerland).
Positive_regulation (transfected) of Gene_expression (transfected) of OPCML-v1
6) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500176 Disease Relevance 0.20 Pain Relevance 0
Using primers specific to the common exons of OPCML transcripts, we found the expression of OPCML in several tumor cell lines (Hep3B, H292, SW480, L1236), where the OPCML-v1 and v2 were totally silenced (Fig. 1F), indicating transcription of OPCML from alternative unknown promoters.
Positive_regulation (found) of Gene_expression (expression) of OPCML in SW480 associated with cancer
7) Confidence 0.44 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500176 Disease Relevance 0.15 Pain Relevance 0
Methylation-sensitive PCR analysis showed that the OPCML promoter was hypermethylated in RAS-transformed human ovarian epithelial cells (T29H) and that treatment with the DNA methyltransferase inhibitor 5'-aza-2'-deoxycytidine promoted demethylation of the OPCML promoter and restored OPCML expression in T29H cells.
Positive_regulation (restored) of Gene_expression (expression) of OPCML in T29H
8) Confidence 0.40 Published 2006 Journal FASEB J. Section Abstract Doc Link 16384911 Disease Relevance 0.37 Pain Relevance 0.06

General Comments

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