INT132515

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Context Info
Confidence 0.51
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 12
Disease Relevance 10.15
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (OPCML) plasma membrane (OPCML)
Anatomy Link Frequency
brain 1
lung 1
OPCML (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 22 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 562 100.00 Very High Very High Very High
Stress 180 100.00 Very High Very High Very High
Adhesions 92 100.00 Very High Very High Very High
Adenocarcinoma 10 100.00 Very High Very High Very High
Nasopharynx Cancer 230 99.84 Very High Very High Very High
Esophageal Cancer 30 99.52 Very High Very High Very High
Brain Tumor 10 99.36 Very High Very High Very High
Carcinoma 130 98.88 Very High Very High Very High
Lymphatic System Cancer 150 98.28 Very High Very High Very High
Ovarian Cancer 48 97.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Loss of OPCML reduces the intercellular adhesion and heterodimeric complex formation and thus impairs the corresponding signaling pathways, thereby promoting the progress of carcinogenesis.
Negative_regulation (Loss) of OPCML associated with adhesions
1) Confidence 0.51 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500176 Disease Relevance 0.97 Pain Relevance 0
OPCML downregulation was not due to genetic deletion
Negative_regulation (downregulation) of OPCML
2) Confidence 0.51 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500176 Disease Relevance 0.64 Pain Relevance 0
Our present study further verifies that OPCML can function as a broad TSG and is frequently inactivated epigenetically in multiple carcinomas and lymphomas, including NPC, esophageal, lung, gastric, hepatocellular, colorectal, breast, cervical and prostate carcinomas.
Negative_regulation (inactivated) of OPCML in lung associated with lymphatic system cancer, nasopharynx cancer, prostate cancer and carcinoma
3) Confidence 0.51 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500176 Disease Relevance 1.11 Pain Relevance 0
Thus, the downregulation of OPCML-v1 appeared to be tumor-specific.
Negative_regulation (downregulation) of OPCML-v1 associated with cancer
4) Confidence 0.51 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500176 Disease Relevance 0.65 Pain Relevance 0
Thus, downregulation of OPCML appears not to be due to genetic deletion, but rather predominantly to epigenetic silencing.


Negative_regulation (downregulation) of OPCML
5) Confidence 0.51 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500176 Disease Relevance 0.89 Pain Relevance 0
Opioid binding protein/cell adhesion molecule-like gene (OPCML), a recently identified tumor-suppressor, is frequently inactivated by allele loss and CpG island promoter methylation in epithelial ovarian cancer.
Negative_regulation (inactivated) of OPCML associated with cancer, ovarian cancer, opioid and adhesions
6) Confidence 0.43 Published 2006 Journal FASEB J. Section Abstract Doc Link 16384911 Disease Relevance 0.45 Pain Relevance 0.10
Opioid binding protein/cell adhesion molecule-like gene (OPCML), a recently identified tumor-suppressor, is frequently inactivated by allele loss and CpG island promoter methylation in epithelial ovarian cancer.
Negative_regulation (inactivated) of Opioid binding protein/cell adhesion molecule-like associated with cancer, ovarian cancer, opioid and adhesions
7) Confidence 0.42 Published 2006 Journal FASEB J. Section Abstract Doc Link 16384911 Disease Relevance 0.45 Pain Relevance 0.10
More recent studies also demonstrated that OPCML is highly methylated in lung adenocarcinoma [21] and down-regulated in gastric and brain carcinomas [22], [23], however no study has been reported for NPC and other tumors yet.
Negative_regulation (regulated) of OPCML in brain associated with adenocarcinoma, cancer, nasopharynx cancer and brain tumor
8) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500176 Disease Relevance 1.46 Pain Relevance 0.15
The frequent, predominant epigenetic inactivation of OPCML in multiple malignancies points to the importance of this gene in tumorigenesis.
Negative_regulation (inactivation) of OPCML
9) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500176 Disease Relevance 0.52 Pain Relevance 0
The high incidence of epigenetic inactivation of OPCML in NPC and esophageal carcinoma, both prevalent in our locality, indicates that OPCML methylation could be an epigenetic biomarker for the molecular diagnosis of these tumors.


Negative_regulation (inactivation) of OPCML associated with cancer, nasopharynx cancer and esophageal cancer
10) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500176 Disease Relevance 1.71 Pain Relevance 0
OPCML is a stress- and p53-responsive gene, but this response was often epigenetically impaired by promoter methylation.
Negative_regulation (impaired) of OPCML associated with stress
11) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500176 Disease Relevance 0.64 Pain Relevance 0
The downregulation of OPCML in multiple tumor cell lines might also result from genetic deletion, as it resides in the frequently deleted 11q25 locus.
Negative_regulation (downregulation) of OPCML associated with cancer
12) Confidence 0.37 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500176 Disease Relevance 0.65 Pain Relevance 0

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