INT132517

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Context Info
Confidence 0.45
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.38
Pain Relevance 0.07

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cell adhesion (OPCML) plasma membrane (OPCML)
Anatomy Link Frequency
T29H 2
OPCML (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 1 65.68 Quite High
Disease Link Frequency Relevance Heat
Ovarian Cancer 4 85.56 High High
Cancer 1 69.12 Quite High
Adhesions 1 66.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Methylation-sensitive PCR analysis showed that the OPCML promoter was hypermethylated in RAS-transformed human ovarian epithelial cells (T29H) and that treatment with the DNA methyltransferase inhibitor 5'-aza-2'-deoxycytidine promoted demethylation of the OPCML promoter and restored OPCML expression in T29H cells.
Regulation (promoted) of Regulation (demethylation) of OPCML in T29H
1) Confidence 0.45 Published 2006 Journal FASEB J. Section Abstract Doc Link 16384911 Disease Relevance 0.38 Pain Relevance 0.07

General Comments

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