INT132519

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Context Info
Confidence 0.54
First Reported 2006
Last Reported 2008
Negated 1
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 5.18
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (OPCML) plasma membrane (OPCML)
Anatomy Link Frequency
T29H 1
lung 1
OPCML (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 9 97.38 Very High Very High Very High
medulla 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Catecholamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 36 100.00 Very High Very High Very High
Neuroblastoma 50 99.84 Very High Very High Very High
Pheochromocytoma 33 99.16 Very High Very High Very High
Lung Cancer 56 99.04 Very High Very High Very High
Lymphatic System Cancer 30 99.00 Very High Very High Very High
Cancer 251 98.96 Very High Very High Very High
Apoptosis 5 98.46 Very High Very High Very High
Carcinoma 26 98.44 Very High Very High Very High
Medulloblastoma 1 98.40 Very High Very High Very High
Brain Tumor 3 97.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We identified OPCML as a down-regulated gene through in silico subtraction.
Regulation (regulated) of OPCML
1) Confidence 0.54 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500176 Disease Relevance 0.55 Pain Relevance 0
Methylation-sensitive PCR analysis showed that the OPCML promoter was hypermethylated in RAS-transformed human ovarian epithelial cells (T29H) and that treatment with the DNA methyltransferase inhibitor 5'-aza-2'-deoxycytidine promoted demethylation of the OPCML promoter and restored OPCML expression in T29H cells.
Regulation (demethylation) of OPCML in T29H
2) Confidence 0.45 Published 2006 Journal FASEB J. Section Abstract Doc Link 16384911 Disease Relevance 0.37 Pain Relevance 0.07
To our knowledge, OPCML promoter methylation has not previously been reported in neuroblastoma or phaeochromocytoma.
Neg (not) Regulation (reported) of OPCML associated with neuroblastoma and pheochromocytoma
3) Confidence 0.37 Published 2008 Journal Endocrine-Related Cancer Section Body Doc Link PMC2519165 Disease Relevance 1.70 Pain Relevance 0
We further showed that OPCML is a stress-responsive and p53-regulated gene, with the response abrogated when the promoter becomes methylated.
Regulation (regulated) of OPCML associated with stress
4) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500176 Disease Relevance 1.16 Pain Relevance 0
Given that opioids have demonstrated growth inhibitory and pro-apoptotic effects in lung cancer cells [29-31], it is perhaps not surprising that the OPCML promoter CpG island might be a target for DNA methylation in lung cancer.
Spec (might) Regulation (target) of OPCML in lung associated with lung cancer, apoptosis and opioid
5) Confidence 0.20 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2206053 Disease Relevance 1.40 Pain Relevance 0.19

General Comments

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