INT132523

Context Info Confidence 0.29 First Reported 2006 Last Reported 2006 Negated 0 Speculated 1 Reported most in Abstract Documents 2 Total Number 3 Disease Relevance 1.29 Pain Relevance 0.18

cell differentiation (RASGRP1) Golgi apparatus (RASGRP1) endoplasmic reticulum (RASGRP1) cytoplasm (RASGRP1) cytosol (RASGRP1) lipid binding (RASGRP1)

RASGRP1 (Homo sapiens)

Pain Link Frequency Relevance Heat Opioid 2 91.16 palliative 3 45.44 Pain 1 14.60 dexamethasone 2 5.00 Spinal cord 1 5.00 Analgesic 1 5.00 Intractable pain 1 5.00 addiction 1 5.00 Kinase C 1 5.00

Disease Link Frequency Relevance Heat Cancer 14 99.44 Ovarian Cancer 8 99.32 Adhesions 3 92.36 Apoptosis 8 71.36 Metastasis 11 56.80 Breast Cancer 25 50.00 Lung Cancer 2 31.72 Pain 1 14.60 Hypercalcemia 3 5.00 Multiple Myeloma 3 5.00

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Anatomy

Negation

Speculation

Pain term

Disease term

Since elevated activation of the RAS signaling pathway, including overexpression of HER-2/neu and mutations of RAS and BRAF, is common in human ovarian carcinoma, we examined the cellular effect of oncogenic RAS on the expression status of OPCML in a genetically defined human ovarian cancer model.

Spec (examined) Positive_regulation (activation) of Gene_expression (overexpression) of RAS associated with ovarian cancer

1) Confidence 0.29 Published 2006 Journal FASEB J. Section Abstract Doc Link 16384911 Disease Relevance 0.48 Pain Relevance 0.09

Since elevated activation of the RAS signaling pathway, including overexpression of HER-2/neu and mutations of RAS and BRAF, is common in human ovarian carcinoma, we examined the cellular effect of oncogenic RAS on the expression status of OPCML in a genetically defined human ovarian cancer model.

Positive_regulation (overexpression) of Gene_expression (overexpression) of RAS associated with ovarian cancer

2) Confidence 0.29 Published 2006 Journal FASEB J. Section Abstract Doc Link 16384911 Disease Relevance 0.47 Pain Relevance 0.09

Conversely, inhibition of Ras activation resulted in radiosensitization both in rodent cells transfected with Ras and in human tumor cells bearing endogenous mutations in Ras [26].

Positive_regulation (transfected) of Gene_expression (transfected) of Ras associated with cancer

3) Confidence 0.12 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1779467 Disease Relevance 0.34 Pain Relevance 0

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