INT132528

Context Info Confidence 0.65 First Reported 1999 Last Reported 2011 Negated 2 Speculated 0 Reported most in Body Documents 17 Total Number 17 Disease Relevance 5.93 Pain Relevance 0.69

unfolded protein binding (TAPBP) endoplasmic reticulum (TAPBP) protein complex assembly (TAPBP)

Anatomy Link Frequency bowel 4 bone marrow 2 B cell 1 muscle 1 T cell 1 TAPBP (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 59 99.54 spinal inflammation 17 97.88 addiction 6 80.80 epidural 1 70.12 Somatostatin 2 69.24 rheumatoid arthritis 1 48.80 cytokine 61 42.36 tolerance 48 5.00 Pain 27 5.00 cINOD 25 5.00

Disease Link Frequency Relevance Heat Inflammatory Bowel Disease 16 99.82 Infection 163 99.36 Injury 258 98.88 Cancer 185 98.24 Pancreatitis 81 97.92 Low Back Pain 17 97.88 Short Bowel Syndrome 190 97.80 Disease 47 97.44 Appetite Loss 50 96.62 Hyperglycemia 77 94.64

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Not all disease-associated alleles were expressed optimally in the absence of tapasin; furthermore, dependence on tapasin for cell surface expression did not correlate with disease association.

Gene_expression (expressed) of tapasin

1) Confidence 0.65 Published 2006 Journal Arthritis Rheum. Section Body Doc Link 16385505 Disease Relevance 0.08 Pain Relevance 0

METHODS: Cell lines with nonfunctional tapasin were transiently transfected with different B27 subtypes and their site-directed mutants, and surface expression analyzed by flow cytometry.

Gene_expression (transfected) of tapasin

2) Confidence 0.65 Published 2006 Journal Arthritis Rheum. Section Body Doc Link 16385505 Disease Relevance 0.10 Pain Relevance 0

This study suggests that HLA-B27 polymorphism drives the tapasin dependency, rates of intracellular maturation and expressions of homodimers.

Gene_expression (expressions) of tapasin

3) Confidence 0.65 Published 2009 Journal Mol. Immunol. Section Abstract Doc Link 19167761 Disease Relevance 0.12 Pain Relevance 0.13

CONCLUSION: These results indicate that the ability to exhibit optimal cell surface expression in the absence of tapasin is not a prerequisite for susceptibility to AS.

Gene_expression (expression) of tapasin

4) Confidence 0.58 Published 2006 Journal Arthritis Rheum. Section Body Doc Link 16385505 Disease Relevance 0.06 Pain Relevance 0

In contrast, B*2706 showed faster folding and no accumulation in the endoplasmic reticulum in the absence of tapasin.

Neg (absence) Gene_expression (absence) of tapasin in reticulum

5) Confidence 0.58 Published 2006 Journal J. Immunol. Section Abstract Doc Link 17082617 Disease Relevance 0.24 Pain Relevance 0.15

HLA-B*2704, an allotype associated with ankylosing spondylitis, is critically dependent on transporter associated with antigen processing and relatively independent of tapasin and immunoproteasome for maturation, surface expression, and T cell recognition: relationship to B*2705 and B*2706.

Gene_expression (expression) of tapasin in T cell associated with spinal inflammation

6) Confidence 0.58 Published 2006 Journal J. Immunol. Section Title Doc Link 17082617 Disease Relevance 0.28 Pain Relevance 0.19

This suggests that TAPA and RAPA may be equally effective in assessing physical activity of older adults in clinical practice.

Gene_expression (effective) of TAPA

7) Confidence 0.57 Published 2008 Journal Prev Chronic Dis Section Body Doc Link PMC2248772 Disease Relevance 0 Pain Relevance 0

Guedon and colleagues [103] performed biopsies in the duodenum of seven adults (all with inflammatory bowel disease) before TPN, after about 3 weeks of TPN, and after discontinuing TPN and restarting oral feedings.

Gene_expression (discontinuing) of TPN in bowel associated with inflammation

8) Confidence 0.40 Published 2005 Journal BMC Nurs Section Body Doc Link PMC549542 Disease Relevance 0.31 Pain Relevance 0.05

Since its introduction, TPN has been a life saving nutrient to severely malnourished patients.

Gene_expression (introduction) of TPN

9) Confidence 0.40 Published 2005 Journal BMC Nurs Section Body Doc Link PMC549542 Disease Relevance 0.82 Pain Relevance 0

Guedon and colleagues [103] performed biopsies in the duodenum of seven adults (all with inflammatory bowel disease) before TPN, after about 3 weeks of TPN, and after discontinuing TPN and restarting oral feedings.

Gene_expression (discontinuing) of TPN in bowel associated with inflammation

10) Confidence 0.40 Published 2005 Journal BMC Nurs Section Body Doc Link PMC549542 Disease Relevance 0.32 Pain Relevance 0.05

Guedon and colleagues [103] performed biopsies in the duodenum of seven adults (all with inflammatory bowel disease) before TPN, after about 3 weeks of TPN, and after discontinuing TPN and restarting oral feedings.

Gene_expression (discontinuing) of TPN in bowel associated with inflammation

11) Confidence 0.40 Published 2005 Journal BMC Nurs Section Body Doc Link PMC549542 Disease Relevance 0.31 Pain Relevance 0.05

The longer the residual small bowel, the shorter the duration of TPN, and the fewer infections [5,96].

Gene_expression (duration) of TPN in bowel associated with infection

12) Confidence 0.40 Published 2005 Journal BMC Nurs Section Body Doc Link PMC549542 Disease Relevance 0.85 Pain Relevance 0

Provision of TPN after open cholecystectomy does not prevent the decline in muscle protein synthesis observed 24 h after surgery [67].

Gene_expression (Provision) of TPN in muscle

13) Confidence 0.13 Published 1999 Journal Crit Care Section Body Doc Link PMC137235 Disease Relevance 0.24 Pain Relevance 0.07

Although randomized, controlled studies have shown little or no benefit of TPN in well-nourished or slightly malnourished cancer patients undergoing treatments such as surgery, radiation, or chemotherapy,107 those patients with severe malnutrition prior to therapeutic interventions demonstrated improved outcomes following major elective surgery, major trauma, and, in some cases, bone marrow transplantation, when TPN was initiated preoperatively.132,133

Gene_expression (initiated) of TPN in bone marrow associated with appetite loss, cancer and injury

14) Confidence 0.11 Published 2008 Journal Eplasty Section Body Doc Link PMC2206003 Disease Relevance 0.59 Pain Relevance 0

Although randomized, controlled studies have shown little or no benefit of TPN in well-nourished or slightly malnourished cancer patients undergoing treatments such as surgery, radiation, or chemotherapy,107 those patients with severe malnutrition prior to therapeutic interventions demonstrated improved outcomes following major elective surgery, major trauma, and, in some cases, bone marrow transplantation, when TPN was initiated preoperatively.132,133

Neg (no) Gene_expression (benefit) of TPN in bone marrow associated with appetite loss, cancer and injury

15) Confidence 0.11 Published 2008 Journal Eplasty Section Body Doc Link PMC2206003 Disease Relevance 0.72 Pain Relevance 0

When artificial nutrition is indicated, EN is preferred over TPN, because it reduces complications and mortality in AP when compared with TPN.

Gene_expression (preferred) of TPN associated with pancreatitis

16) Confidence 0.09 Published 2011 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2929521 Disease Relevance 0.74 Pain Relevance 0

Other functional important immunoglobulins including a B cell differentiation antigen CD19, a TAP binding like protein and several TNFSF members are also on the list.

Gene_expression (members) of TAP binding like protein in B cell

17) Confidence 0.05 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1522023 Disease Relevance 0.17 Pain Relevance 0

General Comments

This test has worked.