INT132529

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Context Info
Confidence 0.47
First Reported 2005
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 1.43
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (TAPBP) endoplasmic reticulum (TAPBP) protein complex assembly (TAPBP)
Anatomy Link Frequency
bowel 1
cortex 1
TAPBP (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 8 95.88 Very High Very High Very High
addiction 3 90.96 High High
Inflammation 17 42.48 Quite Low
imagery 6 22.12 Low Low
insula 2 12.04 Low Low
tolerance 23 8.36 Low Low
cytokine 22 5.00 Very Low Very Low Very Low
Pain 22 5.00 Very Low Very Low Very Low
cINOD 10 5.00 Very Low Very Low Very Low
Thalamus 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatitis 76 99.88 Very High Very High Very High
Low Back Pain 8 95.88 Very High Very High Very High
Disease 9 94.68 High High
Infection 57 75.84 Quite High
Liver Failure 2 71.88 Quite High
Lower Respiratory Tract Infection 2 69.48 Quite High
Sepsis 94 68.52 Quite High
Short Bowel Syndrome 76 67.88 Quite High
Gastric Outlet Obstruction 1 64.08 Quite High
Pressure And Volume Under Development 3 55.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: Amino acids at positions 114, 116, and 152 in the different B27 subtypes were shown to perform key roles in defining a requirement for interaction with tapasin.
tapasin Binding (interaction) of
1) Confidence 0.47 Published 2006 Journal Arthritis Rheum. Section Body Doc Link 16385505 Disease Relevance 0.08 Pain Relevance 0
Both interaction with tapasin and thermostability were higher for B*2705 than for B*1402 and higher for B*1402 than for B*1403, suggesting that the repertoires of the B*1402-bound peptide and especially the B*1403-bound peptide were less optimized than that of B*2705.
tapasin Binding (interaction) of
2) Confidence 0.47 Published 2008 Journal Arthritis Rheum. Section Body Doc Link 19035480 Disease Relevance 0 Pain Relevance 0
Association with calnexin or tapasin was analyzed by coprecipitation with chaperone-specific antibodies, and surface expression was estimated by flow cytometry.
tapasin Binding (Association) of
3) Confidence 0.47 Published 2008 Journal Arthritis Rheum. Section Body Doc Link 19035480 Disease Relevance 0.08 Pain Relevance 0
HLA-B27 polymorphism at position 116 critically influences the association with TAP/tapasin, intracellular trafficking and conformational homodimers formation.
tapasin Binding (association) of
4) Confidence 0.47 Published 2009 Journal Mol. Immunol. Section Title Doc Link 19167761 Disease Relevance 0.19 Pain Relevance 0.18
Andorsky and his co-workers [96] also emphasized that residual bowel length was highly correlated with duration of TPN.
TPN Binding (duration) of in bowel
5) Confidence 0.22 Published 2005 Journal BMC Nurs Section Body Doc Link PMC549542 Disease Relevance 0.28 Pain Relevance 0
Monitoring TPN complications
TPN Binding (complications) of
6) Confidence 0.22 Published 2005 Journal BMC Nurs Section Body Doc Link PMC549542 Disease Relevance 0.08 Pain Relevance 0
The dorsal portion seems to be functionally associated with the TPN, whereas the ventral portion, along with the retrosplenial cortex (BA 29 and BA 30), is selectively interlinked with the TNN.
TPN Binding (associated) of in cortex
7) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948030 Disease Relevance 0 Pain Relevance 0
When artificial nutrition is indicated, EN is preferred over TPN, because it reduces complications and mortality in AP when compared with TPN.
TPN Binding (compared) of associated with pancreatitis
8) Confidence 0.05 Published 2011 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2929521 Disease Relevance 0.73 Pain Relevance 0

General Comments

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