INT132531

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Context Info
Confidence 0.49
First Reported 2005
Last Reported 2008
Negated 1
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 2.84
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (TAPBP) endoplasmic reticulum (TAPBP) protein complex assembly (TAPBP)
Anatomy Link Frequency
T cell 2
TAPBP (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 3 100.00 Very High Very High Very High
spinal inflammation 15 98.18 Very High Very High Very High
Inflammation 28 74.56 Quite High
cytokine 27 31.72 Quite Low
tolerance 16 5.00 Very Low Very Low Very Low
corticosteroid 10 5.00 Very Low Very Low Very Low
cINOD 10 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
vincristine 6 5.00 Very Low Very Low Very Low
methotrexate 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Spondylarthritis 6 99.18 Very High Very High Very High
Low Back Pain 15 98.18 Very High Very High Very High
Fistula 6 97.84 Very High Very High Very High
Ileus 1 96.64 Very High Very High Very High
Infection 63 95.36 Very High Very High Very High
Disease 18 93.56 High High
Injury 118 83.16 Quite High
Frailty 36 77.84 Quite High
Inflammatory Bowel Disease 8 75.12 Quite High
Cancer 87 75.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Spondylarthritis-associated and non-spondylarthritis-associated B27 subtypes differ in their dependence upon tapasin for surface expression and their incorporation into the peptide loading complex.
Positive_regulation (dependence) of tapasin associated with addiction and spondylarthritis
1) Confidence 0.49 Published 2006 Journal Arthritis Rheum. Section Title Doc Link 16385505 Disease Relevance 0.48 Pain Relevance 0.33
Not all disease-associated alleles were expressed optimally in the absence of tapasin; furthermore, dependence on tapasin for cell surface expression did not correlate with disease association.
Positive_regulation (dependence) of tapasin
2) Confidence 0.49 Published 2006 Journal Arthritis Rheum. Section Body Doc Link 16385505 Disease Relevance 0.07 Pain Relevance 0
OBJECTIVE: B27 subtypes associated with susceptibility to ankylosing spondylitis (AS), and those reported not to be associated with AS, are found to differ in the amino acids that are known in other HLA class I molecules to alter the requirements for tapasin and incorporation into the peptide loading complex.
Positive_regulation (requirements) of tapasin associated with spinal inflammation
3) Confidence 0.49 Published 2006 Journal Arthritis Rheum. Section Abstract Doc Link 16385505 Disease Relevance 0.44 Pain Relevance 0.33
HLA-B*2704, an allotype associated with ankylosing spondylitis, is critically dependent on transporter associated with antigen processing and relatively independent of tapasin and immunoproteasome for maturation, surface expression, and T cell recognition: relationship to B*2705 and B*2706.
Neg (independent) Positive_regulation (independent) of tapasin in T cell associated with spinal inflammation
4) Confidence 0.49 Published 2006 Journal J. Immunol. Section Title Doc Link 17082617 Disease Relevance 0.27 Pain Relevance 0.19
We analyzed the influence of tapasin, TAP, and immunoproteasome induction on maturation, surface expression, and T cell allorecognition of B*2704 and compared some of these features with B*2705 and B*2706, allotypes not associated to disease.
Spec (analyzed) Positive_regulation (induction) of tapasin in T cell associated with disease
5) Confidence 0.45 Published 2006 Journal J. Immunol. Section Abstract Doc Link 17082617 Disease Relevance 0.26 Pain Relevance 0.17
Pironi and colleagues [104] performed endoscopic biopsies in 2 adult patients who underwent long-term TPN for the treatment of a postoperative enterocuteneous fistula, and their results showed changes in villous height and crypth depth after 2 and 3 months of TPN; two months after oral refeeding, the values of morphometric parameters were significantly greater than those observed after TPN and were similar to those controls.
Positive_regulation (observed) of TPN associated with fistula
6) Confidence 0.30 Published 2005 Journal BMC Nurs Section Body Doc Link PMC549542 Disease Relevance 0.29 Pain Relevance 0.03
Pironi and colleagues [104] performed endoscopic biopsies in 2 adult patients who underwent long-term TPN for the treatment of a postoperative enterocuteneous fistula, and their results showed changes in villous height and crypth depth after 2 and 3 months of TPN; two months after oral refeeding, the values of morphometric parameters were significantly greater than those observed after TPN and were similar to those controls.
Positive_regulation (performed) of TPN associated with fistula
7) Confidence 0.30 Published 2005 Journal BMC Nurs Section Body Doc Link PMC549542 Disease Relevance 0.33 Pain Relevance 0.04
Although no regulation of the TAP1 or TAP2 transporters was found, the TAP-binding protein (TAPBP) which mediates the interaction between de novo produced MHC class I molecules and the transporter associated with antigen processing (TAP), was upregulated.
Positive_regulation (upregulated) of TAPBP
8) Confidence 0.13 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2519092 Disease Relevance 0.07 Pain Relevance 0
Although total parenteral nutrition (TPN) requires central venous access through either peripherally or centrally inserted catheters, the risks of line placement and infection are outweighed by the benefits of adequate nutritional support.
Positive_regulation (requires) of TPN associated with infection
9) Confidence 0.08 Published 2008 Journal Eplasty Section Body Doc Link PMC2206003 Disease Relevance 0.61 Pain Relevance 0

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