INT132568

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Context Info
Confidence 0.33
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 4.86
Pain Relevance 2.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasmic membrane-bounded vesicle (RFFL) ligase activity (RFFL) cytoplasm (RFFL)
Anatomy Link Frequency
SH-SY5Y 2
RFFL (Homo sapiens)
Pain Link Frequency Relevance Heat
diclofenac 27 99.98 Very High Very High Very High
aspirin 3 80.08 Quite High
cINOD 18 78.40 Quite High
Inflammation 6 75.00 Quite High
Pain 3 50.76 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 33 99.58 Very High Very High Very High
Stress 27 99.52 Very High Very High Very High
Death 6 82.88 Quite High
INFLAMMATION 9 75.00 Quite High
Neuroblastoma 3 68.12 Quite High
Colon Cancer 3 54.60 Quite High
Pain 3 50.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Diclofenac suppressed the activation of caspases induced by both ER stresses.
Negative_regulation (suppressed) of Positive_regulation (activation) of caspases associated with stress and diclofenac
1) Confidence 0.33 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16388830 Disease Relevance 1.75 Pain Relevance 0.77
Diclofenac suppressed the activation of caspases induced by both ER stresses.
Negative_regulation (suppressed) of Positive_regulation (induced) of caspases associated with stress and diclofenac
2) Confidence 0.33 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16388830 Disease Relevance 1.75 Pain Relevance 0.77
Diclofenac inhibited ER-stress-induced apoptosis of SH-SY5Y cells by suppressing the activation of caspases in the intrinsic apoptotic pathway.
Negative_regulation (suppressing) of Positive_regulation (activation) of caspases in SH-SY5Y associated with stress, apoptosis and diclofenac
3) Confidence 0.33 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16388830 Disease Relevance 1.37 Pain Relevance 0.55

General Comments

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