INT132573

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Context Info
Confidence 0.42
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 11.52
Pain Relevance 5.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TH1L) nucleus (TH1L)
Anatomy Link Frequency
Th1 cells 4
T cells 4
monocyte 3
keratinocytes 2
macrophage 1
TH1L (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 633 100.00 Very High Very High Very High
antidepressant 13 99.98 Very High Very High Very High
Catecholamine 6 98.52 Very High Very High Very High
monoamine 4 98.28 Very High Very High Very High
Inflammation 606 95.48 Very High Very High Very High
noradrenaline 3 94.76 High High
Arthritis 88 94.32 High High
Desipramine 2 93.08 High High
Serotonin 3 92.24 High High
fluoxetine 2 91.32 High High
Disease Link Frequency Relevance Heat
Infection 155 99.68 Very High Very High Very High
Organ Transplantation 5 99.38 Very High Very High Very High
Recurrence 24 99.16 Very High Very High Very High
Sprains And Strains 33 99.02 Very High Very High Very High
Fever 5 99.00 Very High Very High Very High
Disease 393 97.76 Very High Very High Very High
Stress 125 96.72 Very High Very High Very High
Disease Progression 9 95.68 Very High Very High Very High
INFLAMMATION 648 95.48 Very High Very High Very High
Hypersensitivity 81 95.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Antidepressants suppress production of the Th1 cytokine interferon-gamma, independent of monoamine transporter blockade.
Negative_regulation (suppress) of Gene_expression (production) of Th1 associated with antidepressant, monoamine and cytokine
1) Confidence 0.42 Published 2006 Journal Eur Neuropsychopharmacol Section Title Doc Link 16388933 Disease Relevance 0.24 Pain Relevance 0.96
In the murine model, several reports showed that a downregulation of Th1 cytokine production and an induction of a Th2 response lead to a high IgE levels.
Negative_regulation (downregulation) of Gene_expression (production) of Th1 associated with cytokine
2) Confidence 0.24 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685643 Disease Relevance 0.46 Pain Relevance 0.14
Although these hypotheses were failing, the suggested mechanism was overproduction of T helper 2 (Th)2 cells as a consequence of diminished infections and consequent diminished production of Th1 cells.
Negative_regulation (diminished) of Gene_expression (production) of Th1 in Th1 cells associated with infection
3) Confidence 0.23 Published 2008 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2868866 Disease Relevance 0.70 Pain Relevance 0.04
The immunosuppressive effect of glucocorticoids after organ transplantation is mainly due to preferential blockade of Th1 cytokine expression and promotion of a Th2 cytokine-secreting profile.
Negative_regulation (blockade) of Gene_expression (expression) of Th1 associated with organ transplantation and cytokine
4) Confidence 0.21 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.77 Pain Relevance 0.26
For instance, the generation of Th1 cells can be effectively blocked by high concentrations of IL-4, even in the presence of IL-12 [72].
Negative_regulation (blocked) of Gene_expression (generation) of Th1 in Th1 cells
5) Confidence 0.20 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 0.64 Pain Relevance 0.27
Patients who suffered relapse, showed neither significant elevation of Th1 cytokines nor downregulation of IL-10, at this time point, although TGF-?
Negative_regulation (downregulation) of Gene_expression (cytokines) of Th1 associated with recurrence and cytokine
6) Confidence 0.18 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2910702 Disease Relevance 0.57 Pain Relevance 0.22
This Th2-like cytokine downregulates monocyte/macrophage cytotoxicity and cytokine production [87], including that of TNF-?
Negative_regulation (downregulates) of Gene_expression (cytokine) of Th2-like in monocyte associated with cytokine
7) Confidence 0.16 Published 2000 Journal Arthritis Res Section Body Doc Link PMC130001 Disease Relevance 0.93 Pain Relevance 0.65
We could indeed show that Th2 cytokines do not induce hBD-2 expression in cultured keratinocytes [18] and that Th2 cytokines repress the Th1 induced expression (not shown here), as was previously shown for hBD-3 [43].
Negative_regulation (repress) of Gene_expression (expression) of Th1 in keratinocytes associated with cytokine
8) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2649503 Disease Relevance 1.12 Pain Relevance 0.54
Glucocorticoids and catecholamines mediate a Th2 shift by up-regulating Th2 cytokine production and also by suppressing APCs and Th1 cytokine synthesis [34, 35].
Negative_regulation (suppressing) of Gene_expression (synthesis) of Th1 associated with catecholamine and cytokine
9) Confidence 0.15 Published 2009 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2723676 Disease Relevance 1.28 Pain Relevance 0.54
In vitro, using allergen-induced human Th1 and Th2 clones both Th1 and Th2 cytokines production are equally inhibited by selective PDE4 inhibitors [55].
Negative_regulation (inhibited) of Gene_expression (production) of Th1 associated with cytokine
10) Confidence 0.14 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.26 Pain Relevance 0.17
In animal studies, PDE4 inhibitors inhibit antigen-mediated T cell proliferation and skew the T cell cytokine profile toward a Th2 phenotype by downregulating the expression or production of Th1 cytokines without affecting Th2 cytokine expression [58,59].
Negative_regulation (downregulating) of Gene_expression (production) of Th1 in T cell associated with cytokine
11) Confidence 0.14 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.24 Pain Relevance 0.46
In vitro, high concentrations of theophylline suppress CD4+ expression of both Th1 and Th2, excluding IL-5, cytokines probably via inhibition of phosphodiesterases [33,34].
Negative_regulation (suppress) of Gene_expression (expression) of Th1 associated with cytokine
12) Confidence 0.14 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.55 Pain Relevance 0.26
To our knowledge the only molecules known to regulate FAAH activity are the TH1 cytokines IL-12 and IFN?
Negative_regulation (knowledge) of Gene_expression (cytokines) of TH1 associated with cytokine
13) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 0.64 Pain Relevance 0.13
Strains of the genus Bifidobacterium have been shown to polarized Th2/Th1 responses in a specific manner, thereby modulating unbalanced cytokine production characteristic of either Th2-type (e.g. allergy) or Th1-type diseases (e.g.
Negative_regulation (polarized) of Gene_expression (responses) of Th1 associated with hypersensitivity, disease, sprains and strains and cytokine
14) Confidence 0.09 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2635381 Disease Relevance 1.28 Pain Relevance 0.19
This Th2-like cytokine downregulates monocyte/macrophage cytotoxicity and cytokine production [87], including that of TNF-?
Negative_regulation (downregulates) of in macrophage Gene_expression (cytokine) of Th2-like in monocyte associated with cytokine
15) Confidence 0.05 Published 2000 Journal Arthritis Res Section Body Doc Link PMC130001 Disease Relevance 0.93 Pain Relevance 0.65
The decreased production of Th1 cytokines in many cellular types was reported as an IL-10-induced adaptative immune response, by interfering on antigen-presenting cells and T cells, possibly via inhibition of NF?
Negative_regulation (decreased) of Gene_expression (production) of Th1 in T cells associated with cytokine
16) Confidence 0.04 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2797601 Disease Relevance 0.91 Pain Relevance 0.28

General Comments

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