INT132575

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Context Info
Confidence 0.20
First Reported 2002
Last Reported 2010
Negated 3
Speculated 3
Reported most in Body
Documents 57
Total Number 60
Disease Relevance 22.06
Pain Relevance 2.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NR1H4) signal transduction (NR1H4) nucleus (NR1H4)
Anatomy Link Frequency
CAR 4
colon 2
nucleus 1
bile 1
NR1H4 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 347 100.00 Very High Very High Very High
Bile 18 99.56 Very High Very High Very High
Kinase C 9 98.00 Very High Very High Very High
cytokine 96 97.12 Very High Very High Very High
cINOD 39 95.60 Very High Very High Very High
Arthritis 38 93.28 High High
Inflammation 205 91.84 High High
antagonist 52 87.84 High High
metalloproteinase 173 81.08 Quite High
imagery 11 75.44 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 464 99.88 Very High Very High Very High
Colon Cancer 431 99.78 Very High Very High Very High
Endometriosis (extended) 15 99.56 Very High Very High Very High
Breast Cancer 154 98.64 Very High Very High Very High
Lymphatic System Cancer 45 98.60 Very High Very High Very High
Apoptosis 338 96.72 Very High Very High Very High
Disease 139 96.24 Very High Very High Very High
Malignant Neoplastic Disease 92 95.20 Very High Very High Very High
INFLAMMATION 250 95.04 Very High Very High Very High
Exfoliative Dermatitis 1 94.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-induced expression of rabbit MMP-1 that involves binding of the RXR:PPAR?
RXR Binding (binding) of
1) Confidence 0.20 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.34 Pain Relevance 0.16
The competitive binding model implicates competition for binding to the degenerate DR-1 site between RXR:PPAR?
RXR Binding (binding) of
2) Confidence 0.20 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.09 Pain Relevance 0.04
This is consistent with the idea that treatment with both ligands might increase the binding of RXR:PPAR?
RXR Spec (might) Binding (binding) of
3) Confidence 0.20 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0 Pain Relevance 0
In this competitive binding model, binding of the RXR:PPAR?
RXR Binding (binding) of
4) Confidence 0.20 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.34 Pain Relevance 0.15
In addition, we hypothesized that LG268, as a ligand for RXR, may also induce increased binding of the heterodimer to the DR-1 site and that combination treatment with both ligands would further increase binding to the DR-1 site since both NHRs would be liganded.
RXR Binding (ligand) of
5) Confidence 0.16 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.08 Pain Relevance 0.04
forms an obligate heterodimer with the retinoid X receptor (RXR:PPAR?)
RXR Binding (obligate) of
6) Confidence 0.16 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.57 Pain Relevance 0.23
and RXR ligands [31].
RXR Binding (ligands) of
7) Confidence 0.16 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.07 Pain Relevance 0.03
Previous work by our laboratory has shown that LG100268 (LG268), a ligand specific for RXR, inhibits IL-1?
RXR Binding (ligand) of
8) Confidence 0.16 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.26 Pain Relevance 0.10
Although Figure 5 suggests that the putative DR-1 element of the DR-1/AP-1 site does not function as a traditional response element for RXR:PPAR?
RXR Binding (element) of
9) Confidence 0.16 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0 Pain Relevance 0
Therefore, to determine whether RXR:PPAR?
RXR Spec (determine) Binding (determine) of
10) Confidence 0.16 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.08 Pain Relevance 0.04
forms an obligate heterodimer with the retinoid X receptor (RXR:PPAR?)
RXR Binding (heterodimer) of
11) Confidence 0.16 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.57 Pain Relevance 0.23
In addition, we document that this inhibition is transcriptionally mediated and involves genetic and epigenetic mechanisms but does not appear to involve competitive binding between RXR:PPAR?
RXR Binding (binding) of
12) Confidence 0.15 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.09 Pain Relevance 0
The

combination of RXR ligand with ciglitazone also cooperatively inhibits the

RXR Binding (combination) of
13) Confidence 0.12 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 1.34 Pain Relevance 0.04
for both RXR and RAR [34, 35], can restore the function of RXR?
RXR Binding (restore) of
14) Confidence 0.12 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.56 Pain Relevance 0.05
and RXR ligands have been shown to differentially recruit subsets of
RXR Binding (ligands) of
15) Confidence 0.12 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.76 Pain Relevance 0.04
Therefore, these findings indicate that RXR?
RXR Binding (indicate) of
16) Confidence 0.12 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.37 Pain Relevance 0
attenuation of ligand-dependent transactivation by RXR/VDR complex in human
RXR Binding (complex) of
17) Confidence 0.12 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.59 Pain Relevance 0
colon cancer cells the combination of the RXR and PPAR?
RXR Binding (combination) of in colon associated with colon cancer
18) Confidence 0.12 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 1.08 Pain Relevance 0.05
RXR is specific for the 9-cis
RXR Binding (specific) of
19) Confidence 0.12 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.82 Pain Relevance 0
ligand with RXR agonist or RAR agonist can enhance the differentiating and
RXR Binding (agonist) of associated with agonist
20) Confidence 0.12 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.95 Pain Relevance 0.14

General Comments

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