INT132585

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Context Info
Confidence 0.01
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.60
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GABBR1, Gabbr1) transcription factor binding (GABBR1, Gabbr1) cytoplasm (GABBR1, Gabbr1)
signal transducer activity (GABBR1, Gabbr1) signal transduction (Gabbr1) extracellular region (GABBR1)
GABBR1 (Homo sapiens)
Gabbr1 (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 1 87.60 High High
depression 1 86.24 High High
Lasting pain 1 85.76 High High
Neuronal excitability 1 73.08 Quite High
Glutamate 1 63.12 Quite High
gABA 1 61.60 Quite High
agonist 2 59.20 Quite High
Disease Link Frequency Relevance Heat
Drug Dependence 1 87.60 High High
Schizophrenia 1 86.84 High High
Depression 1 86.24 High High
Pain 1 85.76 High High
Spasticity 1 85.20 High High
Epilepsy 1 84.72 Quite High
Neurodegenerative Disease 1 82.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The GABAB1 subunit binds the endogenous ligand within its extracellular N-terminus, whilst the GABAB2 subunit is not only essential for the correct trafficking of the GABAB1 subunit to the cell surface, but is also responsible for the interaction of the receptor with its cognate G-protein.
GABAB2 subunit Positive_regulation (essential) of GABAB1 Binding (trafficking) of
1) Confidence 0.01 Published 2005 Journal CNS Drug Rev Section Abstract Doc Link 16389296 Disease Relevance 0.60 Pain Relevance 0.30

General Comments

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