INT132586

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Context Info
Confidence 0.30
First Reported 2000
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 40
Total Number 40
Disease Relevance 26.58
Pain Relevance 9.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hand2) nucleus (Hand2) DNA binding (Hand2)
protein complex (Hand2) transcription factor binding (Hand2)
Anatomy Link Frequency
lymphocytes 4
Th2 cell 4
Th1 cell 3
T cells 3
lung 2
Hand2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 1134 100.00 Very High Very High Very High
Inflammation 1310 99.50 Very High Very High Very High
antagonist 392 99.48 Very High Very High Very High
rheumatoid arthritis 210 98.76 Very High Very High Very High
Neuritis 11 96.88 Very High Very High Very High
chemokine 246 96.76 Very High Very High Very High
Catecholamine 1 96.16 Very High Very High Very High
tolerance 38 94.72 High High
tail-flick 2 91.92 High High
Serotonin 14 90.80 High High
Disease Link Frequency Relevance Heat
Helminth Infection 56 100.00 Very High Very High Very High
Birth Weight 2 99.96 Very High Very High Very High
Alcohol Addiction 24 99.84 Very High Very High Very High
Targeted Disruption 199 99.78 Very High Very High Very High
Spontaneous Abortion 34 99.66 Very High Very High Very High
Infection 241 99.62 Very High Very High Very High
Fungal Infection 4 99.56 Very High Very High Very High
INFLAMMATION 1340 99.50 Very High Very High Very High
Hepatitis C Virus Infection 103 99.46 Very High Very High Very High
Adhesions 66 99.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data predict that the over-expression of CIITA in T cells should lead to the suppressed Th2 differentiation and an enhanced Th1 differentiation of the CIITA-Tg cells upon activation.
Negative_regulation (suppressed) of Th2 in T cells
1) Confidence 0.30 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721999 Disease Relevance 0.63 Pain Relevance 0
The adverse outcomes include decreased birth weight, decreased cord blood cytokines levels (both TH1 and TH2), increased collagen deposition in airway and alveolar walls, abnormal lung function at birth, and suppressed ventilatory responses to postnatal hypoxia (Sekhon et al. 2002; Ueda et al. 1999).
Negative_regulation (decreased) of TH2 in lung associated with birth weight, hypoxia and cytokine
2) Confidence 0.28 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440793 Disease Relevance 1.06 Pain Relevance 0.23
We firstly demonstrated that the selective H4R antagonist, JNJ 7777120, was able to therapeutically reduce Th2 cytokine levels in diseased lung tissue and in response to antigen-specific re-stimulation of T cells.
Negative_regulation (reduce) of Th2 in T cells associated with antagonist and cytokine
3) Confidence 0.28 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.53 Pain Relevance 0.42
Thus, there are major efforts focused on a therapeutic treatment which will decrease the Th2 profile and/or re-direct the immune response from a Th2, IgE-mediated allergic hypersensitivity reaction towards the more favorable Th1 response.
Negative_regulation (decrease) of Th2 associated with hypersensitivity
4) Confidence 0.26 Published 2005 Journal Respir Res Section Body Doc Link PMC555575 Disease Relevance 0.67 Pain Relevance 0.12
A deficiency in TH2 polarization severely impairs the ability of goblet cells to secrete mucus and expel N. brasiliensis [18].
Negative_regulation (deficiency) of TH2 in goblet cells
5) Confidence 0.24 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1769405 Disease Relevance 0.26 Pain Relevance 0
were found in LPS-induced abortion mice, while the Th2 type cytokine IL-4 levels were decreased significantly when injected with LPS on day 7 of pregnancy.
Negative_regulation (decreased) of Th2 associated with spontaneous abortion and cytokine
6) Confidence 0.24 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2958556 Disease Relevance 0.54 Pain Relevance 0.25
The first consideration suggests, that the decreased CCL2 level likely relate to a decreased TH2 lymphocyte activity, as CCL2 induces TH2 polarization.
Negative_regulation (decreased) of TH2 in lymphocyte
7) Confidence 0.24 Published 2005 Journal J Neuroinflammation Section Body Doc Link PMC554759 Disease Relevance 0.57 Pain Relevance 0.28
IL-18 deficiency inhibits both Th1 and Th2 cytokine production but not the clinical symptoms in experimental autoimmune neuritis.
Negative_regulation (inhibits) of Th2 associated with experimental autoimmune neuritis, neuritis and cytokine
8) Confidence 0.22 Published 2007 Journal J. Neuroimmunol. Section Title Doc Link 17218016 Disease Relevance 0.37 Pain Relevance 0.49
For these reasons it is difficult to pin point immunosuppression induced by ethanol as the major factor for the increased prevalence of Strongyloides in chronic alcoholics, because the TH2 response, the most important resistance against this worm in humans [21], [22], is not depressed by ethanol abuse.
Neg (not) Negative_regulation (depressed) of TH2 in TH2 associated with alcohol addiction and helminth infection
9) Confidence 0.22 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2889815 Disease Relevance 0.35 Pain Relevance 0
Th2 cytokine levels in the BAL fluid of C57BL/6 mice were inhibited in comparison with Balb/c mice following sensitization and challenge with Af
Negative_regulation (inhibited) of Th2 associated with aspergillus infection and cytokine
10) Confidence 0.21 Published 2003 Journal Respir Res Section Body Doc Link PMC314399 Disease Relevance 0.81 Pain Relevance 0.23
Notably, a profound reduction in Th2 polarization and the production of the effector Th2 cytokine, IL-13, was observed [6].
Negative_regulation (reduction) of Th2 associated with cytokine
11) Confidence 0.20 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 1.01 Pain Relevance 0.21
Consequently, a broader approach to inhibiting Th2 cytokine production, as possible with H4R antagonists and other small molecule inhibitors of Th2 cell polarization, may prove beneficial.
Negative_regulation (inhibitors) of Th2 in Th2 cell associated with antagonist and cytokine
12) Confidence 0.20 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.50 Pain Relevance 0.34
The exact mechanism for this is as yet unknown, but reduced levels of pro-Th2 cytokines such as IL-4 and IL-6 may explain the reduction in downstream Th2 polarization.
Negative_regulation (reduced) of Th2 associated with cytokine
13) Confidence 0.20 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 0.26 Pain Relevance 0.40
Selective antagonism or gene knockout of H4R has been demonstrated to diminish allergic lung inflammation in a mouse model, with specific reduction of Th2-type cytokines identified in bronchoalveolar lavage fluid (BALF) and from draining lymph node cultures.
Negative_regulation (reduction) of Th2 in lung associated with targeted disruption, inflammation, hypersensitivity, pneumonia and cytokine
14) Confidence 0.20 Published 2010 Journal Respir Res Section Body Doc Link PMC2914735 Disease Relevance 1.00 Pain Relevance 0.27
STAT4 and STAT6 are essential for T helper (Th)1 and Th2 development, Because these are activated by IL-12 and IL-4, respectively.
Negative_regulation (development) of Th2
15) Confidence 0.18 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0.27 Pain Relevance 0.47
In conclusion, we have found that sTNFR treatment of murine model of acute asthma resulted in reduction of airway inflammation, which was accompanied with the reduction of Th2 cytokine and adhesion molecule.
Negative_regulation (reduction) of Th2 associated with asthma, inflammation, adhesions and cytokine
16) Confidence 0.18 Published 2009 Journal Yonsei Medical Journal Section Body Doc Link PMC2730622 Disease Relevance 1.15 Pain Relevance 0.27
Delayed mucus responses to N. brasiliensis infection are associated with an impaired TH2 response [18].
Negative_regulation (impaired) of TH2 associated with infection
17) Confidence 0.18 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1769405 Disease Relevance 0.26 Pain Relevance 0.22
Because Th1 cells are highly sensitive to apoptosis [76], modification of their oxidative status by PPARs may help to normalize the Th1/Th2 balance.
Negative_regulation (normalize) of Th2 in Th1 cells associated with apoptosis
18) Confidence 0.18 Published 2010 Journal PPAR Research Section Body Doc Link PMC2796461 Disease Relevance 0.84 Pain Relevance 0.30
reversed the TH1 cell inhibition of TH2 cell-induced AHR [159].
Negative_regulation (inhibition) of TH2
19) Confidence 0.18 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.53 Pain Relevance 0.14
In preclinical models, T-cell anergy, a decrease in the Th2 response, and an induction of TGF-?
Negative_regulation (decrease) of Th2 in T-cell
20) Confidence 0.17 Published 2009 Journal Respir Res Section Body Doc Link PMC2713210 Disease Relevance 0.69 Pain Relevance 0.29

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