INT132610

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Context Info
Confidence 0.46
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.09
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk2) cytosol (Ntrk2) extracellular region (Bdnf)
plasma membrane (Ntrk2) cytoplasmic membrane-bounded vesicle (Bdnf) kinase activity (Ntrk2)
Anatomy Link Frequency
neurons 1
Bdnf (Mus musculus)
Ntrk2 (Mus musculus)
Pain Link Frequency Relevance Heat
trk B 3 99.78 Very High Very High Very High
antidepressant 14 99.36 Very High Very High Very High
Pyramidal cell 24 98.16 Very High Very High Very High
depression 4 97.76 Very High Very High Very High
Serotonin 1 95.24 Very High Very High Very High
agonist 18 95.00 High High
fluoxetine 2 83.36 Quite High
Inflammatory response 4 76.44 Quite High
monoamine 3 75.00 Quite High
Eae 6 64.24 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 20 98.88 Very High Very High Very High
Depression 4 97.76 Very High Very High Very High
Anxiety Disorder 23 95.64 Very High Very High Very High
INFLAMMATION 17 76.04 Quite High
Hematological Disease 12 75.32 Quite High
Shock 6 71.44 Quite High
Pain 2 54.64 Quite High
Apoptosis 21 34.00 Quite Low
Ganglion Cysts 8 5.00 Very Low Very Low Very Low
Death 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Brain-derived neurotrophic factor (BDNF) influences the growth and plasticity of serotonergic (5-HT) neurons via the activation of trkB receptor. 3.
Brain-derived neurotrophic factor Positive_regulation (activation) of trkB in neurons
1) Confidence 0.46 Published 2005 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 16392030 Disease Relevance 0.20 Pain Relevance 0.47
Activation of TrkB by BDNF has been repeatedly shown to be associated with, and required for, the acquisition of classical conditioned fear in rodent models [34], [35], [36], [37], [38], [39].
BDNF Positive_regulation (Activation) of TrkB associated with anxiety disorder
2) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.62 Pain Relevance 0.25
Dark-rearing is known to down-regulate BDNF-induced activation of TrkB receptors [24], despite increased BDNF protein expression [25].
BDNF Positive_regulation (activation) of TrkB
3) Confidence 0.24 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2686200 Disease Relevance 0 Pain Relevance 0.05
Uniquely, the Trk B receptor (NTRK2) was increased by NGF, but not BDNF, with the increase reaching our threshold cut-off of three times that of untreated cells.
BDNF Positive_regulation (increased) of NTRK2 associated with trk b
4) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2837737 Disease Relevance 0.27 Pain Relevance 0.15

General Comments

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