INT132617

Context Info Confidence 0.42 First Reported 2006 Last Reported 2010 Negated 2 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 1.55 Pain Relevance 0.96

cytosol (Gsr) mitochondrion (Gsr) oxidoreductase activity (Gsr) cytoplasm (Gsr)

Anatomy Link Frequency paw 1 Gsr (Mus musculus)

Pain Link Frequency Relevance Heat Paracetamol 8 98.98 Inflammation 7 96.20 Analgesic 5 88.44

Disease Link Frequency Relevance Heat Pressure And Volume Under Development 6 98.76 INFLAMMATION 7 96.20 Hepatotoxicity 5 86.24 Drug Induced Neurotoxicity 3 84.24 Stress 2 81.92 Death 1 70.64 Body Weight 1 68.88 Injury 1 60.96 Gonorrhea 1 49.48 Mycobacterial Infection 1 48.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Conversely, MeHg exposure increased cerebellar glutathione reductase activity (mean percentage inhibition of 70%), and this phenomenon was not affected by C. paludosa co-administration.

Neg (not) Regulation (affected) of glutathione reductase

1) Confidence 0.42 Published 2007 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 17651315 Disease Relevance 0.29 Pain Relevance 0

Neither paracetamol treatment alone nor pretreatment with W. paludosa altered glutathione reductase and glutathione S-transferase activity or the levels of end-products of lipid peroxidation.

Neg (nor) Regulation (altered) of glutathione reductase associated with paracetamol

2) Confidence 0.40 Published 2006 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 16393474 Disease Relevance 0.60 Pain Relevance 0.63

We also detected the changes in the activities of superoxide dismutase (SOD), glutathione reductase (GRx) and glutathione peroxidase (GPx) of liver in the lambda-carrageenan-induced paw edema in mice to investigate the anti-inflammatory mechanism of FL and FM.

Regulation (changes) of glutathione reductase in paw associated with pressure and volume under development and inflammation

3) Confidence 0.20 Published 2010 Journal Am. J. Chin. Med. Section Abstract Doc Link 20503477 Disease Relevance 0.66 Pain Relevance 0.34

General Comments

This test has worked.