INT132623

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Context Info
Confidence 0.53
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.56
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cyp2e1) oxidoreductase activity (Cyp2e1) endoplasmic reticulum (Cyp2e1)
enzyme binding (Cyp2e1)
Cyp2e1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 14 92.56 High High
Analgesic 6 61.44 Quite High
Disease Link Frequency Relevance Heat
Hepatotoxicity 6 84.24 Quite High
Overdose 2 72.24 Quite High
Toxicity 2 52.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A significant 24-h rhythmicity was demonstrated for CYP2E1 activity, protein levels and mRNA levels.
Transcription (levels) of CYP2E1
1) Confidence 0.53 Published 2009 Journal Yakugaku Zasshi Section Abstract Doc Link 19881208 Disease Relevance 0.28 Pain Relevance 0.50
HNF-1alpha and clock genes may contribute to produce the 24-h rhythm of CYP2E1 mRNA levels.
Transcription (levels) of CYP2E1
2) Confidence 0.53 Published 2009 Journal Yakugaku Zasshi Section Abstract Doc Link 19881208 Disease Relevance 0.22 Pain Relevance 0.48
Mice fed the "Western-style" diet were protected from APAP hepatotoxicity as evidenced by 89% decrease in ALT levels and less centrilobular injury, which was associated with 42% decrease in CYP2E1 mRNA levels.
Transcription (levels) of CYP2E1
3) Confidence 0.49 Published 2006 Journal Microcirculation Section Body Doc Link 16393943 Disease Relevance 0.06 Pain Relevance 0

General Comments

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