INT132665

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Context Info
Confidence 0.59
First Reported 2006
Last Reported 2011
Negated 0
Speculated 2
Reported most in Abstract
Documents 4
Total Number 6
Disease Relevance 2.29
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Ucp1) mitochondrion (Ucp1) transmembrane transport (Ucp1)
Anatomy Link Frequency
skin 2
liver 1
Ucp1 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 6 81.00 Quite High
tolerance 9 53.76 Quite High
Eae 7 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
cerebral cortex 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Neuropeptide 1 5.00 Very Low Very Low Very Low
Inflammatory stimuli 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 133 99.32 Very High Very High Very High
Increased Venous Pressure Under Development 12 99.06 Very High Very High Very High
Targeted Disruption 41 90.64 High High
Body Weight 39 55.36 Quite High
Impaired Glucose Tolerance 4 53.76 Quite High
Hyperinsulinism 6 34.44 Quite Low
Insulin Resistance 6 20.88 Low Low
INFLAMMATION 5 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low
Infection 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that Ucp1-/- mice highly, or at least partly, rely on vasoconstriction for heat conservation to compensate for their UCP1 deficiency and to maintain homeothermy under the condition of normal housing temperature.
Negative_regulation (deficiency) of UCP1 associated with increased venous pressure under development
1) Confidence 0.59 Published 2006 Journal Pflugers Arch. Section Abstract Doc Link 16395600 Disease Relevance 0.26 Pain Relevance 0.08
To investigate the thermoregulatory mechanism in mice lacking uncoupling protein 1 (UCP1) from the viewpoint of heat loss, we measured oxygen consumptions (VO2), skin-surface temperatures (Tskin, an index of heat release), blood flows in the tails, and rectal temperatures (Trectal) of mice housed in an animal room under the standard thermal condition of approximately 23 degrees C.
Spec (investigate) Negative_regulation (lacking) of UCP1 in skin
2) Confidence 0.43 Published 2006 Journal Pflugers Arch. Section Abstract Doc Link 16395600 Disease Relevance 0.07 Pain Relevance 0
Compared with wild-type (Ucp1+/+) mice, adult UCP1-deficient (Ucp1-/-) mice tended to show a reduced VO2.
Negative_regulation (deficient) of UCP1
3) Confidence 0.43 Published 2006 Journal Pflugers Arch. Section Abstract Doc Link 16395600 Disease Relevance 0.13 Pain Relevance 0.07
To investigate the thermoregulatory mechanism in mice lacking uncoupling protein 1 (UCP1) from the viewpoint of heat loss, we measured oxygen consumptions (VO2), skin-surface temperatures (Tskin, an index of heat release), blood flows in the tails, and rectal temperatures (Trectal) of mice housed in an animal room under the standard thermal condition of approximately 23 degrees C.
Spec (investigate) Negative_regulation (lacking) of uncoupling protein 1 in skin
4) Confidence 0.38 Published 2006 Journal Pflugers Arch. Section Abstract Doc Link 16395600 Disease Relevance 0.07 Pain Relevance 0
Additionally, the levels of UCP2 and UCP1 were reduced in the liver and BAT, respectively, in GhrR KO mice relative to WT mice.


Negative_regulation (reduced) of UCP1 in liver
5) Confidence 0.36 Published 2011 Journal BMC Physiol Section Abstract Doc Link PMC3024223 Disease Relevance 0.23 Pain Relevance 0.03
As shown in Fig. 3, the gene and protein expression levels of Ucp-1 and Ucp-3 were down-regulated in ob/ob mice and up-regulated in iNOS-deficient mice as compared to those of wild type mice.
Negative_regulation (down) of Ucp-1 associated with obesity
6) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2881035 Disease Relevance 1.51 Pain Relevance 0

General Comments

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