INT132667

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Context Info
Confidence 0.30
First Reported 2006
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 2.58
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NOS1) oxidoreductase activity (NOS1) cytoskeleton (NOS1)
cytoplasm (NOS1)
Anatomy Link Frequency
pia mater 4
liver 2
microglial cells 2
NOS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Migraine 10 97.32 Very High Very High Very High
Neuronal nitric oxide synthase 2 75.00 Quite High
Endocannabinoid 3 74.32 Quite High
cytokine 1 62.24 Quite High
Sumatriptan 2 53.04 Quite High
Cannabinoid 3 50.40 Quite High
Central nervous system 1 33.20 Quite Low
qutenza 1 19.44 Low Low
COX2 1 10.00 Low Low
cva 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 20 100.00 Very High Very High Very High
Cirrhosis 61 98.94 Very High Very High Very High
Increased Venous Pressure Under Development 15 98.40 Very High Very High Very High
INFLAMMATION 1 98.24 Very High Very High Very High
End Stage Liver Disease 1 97.40 Very High Very High Very High
Headache 10 97.32 Very High Very High Very High
Cv Unclassified Under Development 3 78.08 Quite High
Pressure And Volume Under Development 29 45.84 Quite Low
Hepatopulmonary Syndrome 14 5.00 Very Low Very Low Very Low
Coronary Heart Disease 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we investigated in Wistar rats the effect of air stress on nitric oxide synthase (NOS) mRNA and protein expression in dura and pia mater using real-time polymerase chain reaction and Western blotting, respectively.
Spec (investigated) Regulation (effect) of Transcription (expression) of nitric oxide synthase in pia mater associated with stress
1) Confidence 0.30 Published 2006 Journal Cephalalgia Section Abstract Doc Link 16396662 Disease Relevance 0.88 Pain Relevance 0.43
In the present study, we investigated in Wistar rats the effect of air stress on nitric oxide synthase (NOS) mRNA and protein expression in dura and pia mater using real-time polymerase chain reaction and Western blotting, respectively.
Spec (investigated) Regulation (effect) of Transcription (expression) of NOS in pia mater associated with stress
2) Confidence 0.22 Published 2006 Journal Cephalalgia Section Abstract Doc Link 16396662 Disease Relevance 0.88 Pain Relevance 0.43
Multiple studies using nonspecific NOS inhibitors revealed that diminishing NO production resulted in normalization of the peripheral vascular vasodilatation.[16] Ferguson et al demonstrated that the selective inhibition of iNOS causes peripheral vasoconstriction in patients with cirrhosis but not in healthy-matched controls, suggesting the contribution of NOS in the regulation of peripheral vascular tone and the hyperdynamic circulation of end stage liver disease.[17] Other studies favor eNOS as the leading source of the vascular NO overproduction in the splanchnic arterial circulation.[18–19]
Regulation (regulation) of Transcription (contribution) of NOS in liver associated with cirrhosis, end stage liver disease and increased venous pressure under development
3) Confidence 0.03 Published 2010 Journal Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association Section Body Doc Link PMC3003209 Disease Relevance 0.71 Pain Relevance 0.09
METHODS: The effects of amygdalin extracted from Armeniacae semen on the LPS-stimulated mRNA expressions of cyclooxygenase (COX)-1, COX-2 and inducible nitric oxide synthase (iNOS) in the mouse BV2 microglial cells were investigated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, reverse transcription-polymerase chain reaction (RT-PCR).
Spec (investigated) Regulation (effects) of Transcription (expressions) of nitric oxide synthase in microglial cells
4) Confidence 0.02 Published 2007 Journal Neurol. Res. Section Body Doc Link 17359643 Disease Relevance 0.10 Pain Relevance 0

General Comments

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