INT132668

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Context Info
Confidence 0.18
First Reported 2006
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.72
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NOS1) oxidoreductase activity (NOS1) cytoskeleton (NOS1)
cytoplasm (NOS1)
Anatomy Link Frequency
pia mater 2
NOS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
ketamine 136 94.60 High High
Migraine 5 87.60 High High
Sumatriptan 1 86.48 High High
Inflammatory response 2 77.28 Quite High
Neuronal nitric oxide synthase 1 75.00 Quite High
depression 11 60.24 Quite High
Inflammation 54 50.00 Quite Low
cva 2 7.64 Low Low
cytokine 9 5.00 Very Low Very Low Very Low
Inflammatory marker 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 19 99.84 Very High Very High Very High
Aging 20 96.24 Very High Very High Very High
Cv Unclassified Under Development 4 95.56 Very High Very High Very High
Headache 5 87.60 High High
Endotoxemia 18 77.84 Quite High
INFLAMMATION 60 76.92 Quite High
Sepsis 16 71.52 Quite High
Depression 8 60.24 Quite High
Parkinson's Disease 2 50.40 Quite High
Coronary Heart Disease 11 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inducible NOS mRNA and protein expression levels in dura and pia mater were unaffected by stress.
Neg (unaffected) Negative_regulation (unaffected) of Transcription (expression) of NOS in pia mater associated with stress
1) Confidence 0.18 Published 2006 Journal Cephalalgia Section Abstract Doc Link 16396662 Disease Relevance 0.93 Pain Relevance 0.51
Only one study measured the inducible NOS protein abundance and NOS activity after injection of a cocktail of LPS and IFN-?
Negative_regulation (measured) of Transcription (abundance) of NOS
2) Confidence 0.04 Published 2006 Journal Crit Care Section Body Doc Link PMC1750995 Disease Relevance 0.79 Pain Relevance 0.10
NOS mRNA expression in pulmonary tissues
Negative_regulation (tissues) of Transcription (expression) of NOS
3) Confidence 0.04 Published 2007 Journal J Inflamm (Lond) Section Body Doc Link PMC1876456 Disease Relevance 0 Pain Relevance 0.26

General Comments

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