INT132669

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Context Info
Confidence 0.44
First Reported 2006
Last Reported 2011
Negated 2
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.43
Pain Relevance 2.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NOS1) oxidoreductase activity (NOS1) cytoskeleton (NOS1)
cytoplasm (NOS1)
Anatomy Link Frequency
plasma 4
neuronal 2
pia mater 2
lung 2
NOS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 79 99.70 Very High Very High Very High
amygdala 126 99.04 Very High Very High Very High
long-term potentiation 74 97.12 Very High Very High Very High
gABA 5 90.24 High High
Glutamate 5 89.92 High High
Migraine 5 84.00 Quite High
Sumatriptan 1 82.88 Quite High
Inflammatory response 5 76.76 Quite High
Neuronal nitric oxide synthase 5 75.00 Quite High
Glutamate receptor 1 69.20 Quite High
Disease Link Frequency Relevance Heat
Stress 36 99.04 Very High Very High Very High
Injury 125 98.32 Very High Very High Very High
Aging 20 95.72 Very High Very High Very High
Cv Unclassified Under Development 4 95.04 Very High Very High Very High
Sepsis 95 92.72 High High
Adult Respiratory Distress Syndrome 72 92.28 High High
Headache 5 84.00 Quite High
Endotoxemia 17 77.84 Quite High
INFLAMMATION 31 76.40 Quite High
Depression 11 60.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neither the expression of nNOS protein nor mRNA in lung tissue was increased toward the sham-injured control group at any investigated time point (Figure 2).
Neg (Neither) Positive_regulation (increased) of Transcription (expression) of nNOS in lung
1) Confidence 0.44 Published 2010 Journal Crit Care Section Body Doc Link PMC2945093 Disease Relevance 0.80 Pain Relevance 0.06
Subsequent to enhanced transcription and expression of eNOS and iNOS, both total NOS activity and plasma NOS levels were increased from 12 to 24 hours after the double-hit injury.
Positive_regulation (increased) of Transcription (transcription) of NOS in plasma associated with injury
2) Confidence 0.27 Published 2010 Journal Crit Care Section Body Doc Link PMC2945093 Disease Relevance 0.61 Pain Relevance 0.03
Subsequent to enhanced transcription and expression of eNOS and iNOS, both total NOS activity and plasma NOS levels were increased from 12 to 24 hours after the double-hit injury.
Positive_regulation (enhanced) of Transcription (transcription) of NOS in plasma associated with injury
3) Confidence 0.27 Published 2010 Journal Crit Care Section Body Doc Link PMC2945093 Disease Relevance 0.61 Pain Relevance 0.03
Although neither mRNA nor protein expression of nNOS was increased at any of the evaluated time points, both eNOS and iNOS protein expressions started to increase early after the injury.
Neg (neither) Positive_regulation (increased) of Transcription (expression) of nNOS associated with injury
4) Confidence 0.27 Published 2010 Journal Crit Care Section Body Doc Link PMC2945093 Disease Relevance 0.69 Pain Relevance 0
Inducible NOS mRNA and protein expression levels in dura and pia mater were unaffected by stress.
Positive_regulation (Inducible) of Transcription (expression) of NOS in pia mater associated with stress
5) Confidence 0.20 Published 2006 Journal Cephalalgia Section Abstract Doc Link 16396662 Disease Relevance 0.93 Pain Relevance 0.51
Only one study measured the inducible NOS protein abundance and NOS activity after injection of a cocktail of LPS and IFN-?
Positive_regulation (inducible) of Transcription (abundance) of NOS
6) Confidence 0.05 Published 2006 Journal Crit Care Section Body Doc Link PMC1750995 Disease Relevance 0.78 Pain Relevance 0.10
For the medial amygdala it has been shown that capsaicin significantly increases the expression of neuronal NOS (nNOS) mRNA and protein, as demonstrated by in-situ hybridization and immunohistochemistry [43].
Positive_regulation (increases) of Transcription (expression) of NOS in neuronal associated with qutenza and amygdala
7) Confidence 0.04 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020947 Disease Relevance 0 Pain Relevance 1.46

General Comments

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