INT13267

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Context Info
Confidence 0.40
First Reported 1990
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 3.50
Pain Relevance 2.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pgr) nucleolus (Pgr) nucleus (Pgr)
enzyme binding (Pgr) cytoplasm (Pgr)
Anatomy Link Frequency
uterus 1
arcuate nucleus 1
uterine 1
synapses 1
duct 1
Pgr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 4 100.00 Very High Very High Very High
Dopamine 3 100.00 Very High Very High Very High
Endogenous opioid 3 99.54 Very High Very High Very High
Arthritis 8 98.92 Very High Very High Very High
antagonist 13 98.00 Very High Very High Very High
vagus nerve 138 97.40 Very High Very High Very High
agonist 17 94.72 High High
Dynorphin 7 92.96 High High
Inflammation 25 90.24 High High
addiction 9 88.72 High High
Disease Link Frequency Relevance Heat
Experimental Arthritis 6 98.92 Very High Very High Very High
Disease 31 93.92 High High
Endometriosis 2 93.16 High High
Body Weight 30 91.60 High High
Cancer 46 90.08 High High
Recurrence 40 88.16 High High
Endometrial Stromal Sarcoma 14 87.88 High High
Injury 25 84.76 Quite High
Brain Injury 68 84.08 Quite High
INFLAMMATION 30 83.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some progesterone metabolites have shown little or no affinity for the progesterone receptor but have been found to be potent modulators of the GABAA receptor system.
progesterone receptor Neg (little) Binding (affinity) of
1) Confidence 0.40 Published 1991 Journal Biol. Reprod. Section Abstract Doc Link 1664743 Disease Relevance 0.08 Pain Relevance 0.08
Both the ER and PR protein concentrations and the [3H]Estradiol binding to the high affinity nuclear receptors decreased after ENK treatment during the first two days.
PR Binding (binding) of
2) Confidence 0.29 Published 2000 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 11074353 Disease Relevance 0 Pain Relevance 0.21
Furthermore, the relationship between the AI and protein binding of R- and S-PR was significant in severe AA.
PR Binding (binding) of associated with arthritis
3) Confidence 0.29 Published 1995 Journal Drug Metab. Dispos. Section Abstract Doc Link 7736918 Disease Relevance 0.92 Pain Relevance 0.53
The reason the E2 high did not stimulate PR receptor as profoundly as did E2 low remains obscure, particularly in view of the profound stimulation of mammary duct tissue with luminal formation and secretory activity by the E2 high.
PR Neg (not) Binding (receptor) of in duct
4) Confidence 0.21 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2174401 Disease Relevance 0.15 Pain Relevance 0
levels decrease in the rat uterus as serum P levels increase [15], and that P decreases sensitivity of cells to estrogens by inhibiting ER-mediated transactivation via direct interactions of ligand bound PR and ER?
PR Binding (bound) of in uterus
5) Confidence 0.20 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1586009 Disease Relevance 0 Pain Relevance 0.07
B binding to DNA by PR which did not depend upon the presence of ligand and, presumably, was not related to the transcriptional activity of PR.
PR Binding (binding) of
6) Confidence 0.16 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2222592 Disease Relevance 0.54 Pain Relevance 0.03
that, when progesterone is present, the progesterone receptor forms a heterodimer with NF-?
progesterone receptor Binding (heterodimer) of
7) Confidence 0.15 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2222592 Disease Relevance 0.61 Pain Relevance 0.10
Unlike the majority of older progestogens, which were 19-nortestosterone derivatives synthesized primarily for their antigonadotropic activity as a component of hormonal contraception in combination with an estrogen, nomegestrol acetate is a 19-norprogesterone derivative designed to bind specifically to the progesterone receptor, and is relatively lacking in affinity for other steroid receptors.
progesterone receptor Binding (bind) of
8) Confidence 0.11 Published 2010 Journal Drugs Section Abstract Doc Link 20329803 Disease Relevance 0.08 Pain Relevance 0
These results imply that synapses with lower Pr (i.e., larger PPR) are more closely associated with larger numbers of release sites, as is the case for type I DMX neurons.


Pr Binding (associated) of in synapses associated with vagus nerve
9) Confidence 0.06 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2978217 Disease Relevance 0 Pain Relevance 0.23
uterine insulin-like growth factor 1, progesterone receptor, and complement
progesterone receptor Binding (complement) of in uterine
10) Confidence 0.05 Published 2009 Journal Journal of Toxicology Section Body Doc Link PMC2809433 Disease Relevance 0.31 Pain Relevance 0
Endosulfan and alachlor have been found to bind to the estrogen receptor as well as the progesterone receptor [81].
progesterone receptor Binding (bind) of
11) Confidence 0.03 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1524969 Disease Relevance 0 Pain Relevance 0.35
The distributions of endogenous opioid peptides are known to overlap with progesterone receptors (PR) in the arcuate nucleus.
PR Binding (overlap) of in arcuate nucleus associated with endogenous opioid
12) Confidence 0.02 Published 2005 Journal Neuroendocrinology Section Abstract Doc Link 15976512 Disease Relevance 0 Pain Relevance 0.30
Ligands of four targets (dopamine D2 receptor, opioid delta-receptor, factor Xa serine protease, and progesterone receptor) were taken from the second half to form the respective reference sets.
progesterone receptor Binding (Ligands) of associated with dopamine and opioid
13) Confidence 0.02 Published 2003 Journal J Chem Inf Comput Sci Section Abstract Doc Link 12653501 Disease Relevance 0 Pain Relevance 0.15
The sigma receptor is not the traditionally recognized cytosolic progesterone receptor and is found in crude membrane fractions.
progesterone receptor Binding (recognized) of
14) Confidence 0.01 Published 1990 Journal Ciba Found. Symp. Section Abstract Doc Link 1963396 Disease Relevance 0.06 Pain Relevance 0.15
Medroxyprogesterone acetate (MPA) and megestrole acetate are synthetic derivatives of progesterone that exert their activity after binding to the progesterone receptor [79].
progesterone receptor Binding (binding) of
15) Confidence 0.01 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2674046 Disease Relevance 0.76 Pain Relevance 0

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