INT132685

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Context Info
Confidence 0.42
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.89
Pain Relevance 2.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (NTRK2) plasma membrane (NTRK2)
Anatomy Link Frequency
RVM 1
hippocampus 1
NTRK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
bDMF 45 100.00 Very High Very High Very High
Rostral ventromedial medulla 7 99.46 Very High Very High Very High
Hippocampus 1 99.44 Very High Very High Very High
IPN 1 98.76 Very High Very High Very High
Inflammation 1 98.48 Very High Very High Very High
Central grey 4 95.48 Very High Very High Very High
Spinal cord 1 94.96 High High
Pain 6 90.04 High High
cytokine 1 89.40 High High
nMDA receptor 1 88.24 High High
Disease Link Frequency Relevance Heat
Disease 255 99.24 Very High Very High Very High
Inflammatory Pain 1 98.76 Very High Very High Very High
INFLAMMATION 3 98.48 Very High Very High Very High
Schizophrenia 21 95.48 Very High Very High Very High
Urological Neuroanatomy 4 95.48 Very High Very High Very High
Cognitive Disorder 3 94.96 High High
Psychosis 10 94.68 High High
Depression 4 94.12 High High
Catalepsy 1 92.46 High High
Nociception 1 91.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
2 receptors, and the highest affinity for histamine H1 receptors (olanzapine is the most potent histamine H1 antagonist known).19,20 Olanzapine selectively reduced the activity of dopaminergic mesolimbic (A10) neurons but not dopaminergic striatal (A9) neuron fire and, in animal studies, counteracted conditioned avoidance behavior (test of antipsychotic efficacy) at a dose that was not sufficient to induce catalepsy (test of motor side effect).21 More recently, preclinical studies showed that olanzapine efficacy on psychotic and cognitive symptoms of schizophrenia may be represented by its facilitating effect on N-methyl-D-aspartic acid, which can favor brain derived neurotrophic factor (BDNF) expression.22,23 According to another study, treatment with olanzapine markedly restored the reduction of both BDNF and TrkB receptors in hippocampus, associated with previous treatment with haloperidol.24 Other studies mentioned that olanzapine efficacy on negative and depressive symptoms of schizophrenia might be related to inhibition of norepinephrine transporter25 and modulation of cytokine plasma level, as interleukin-2 declined after 8-week olanzapine treatment.26

Side effects of olanzapine

Negative_regulation (reduction) of TrkB in hippocampus associated with depression, schizophrenia, cytokine, cognitive disorder, catalepsy, antagonist, psychosis, hippocampus and bdmf
1) Confidence 0.42 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938306 Disease Relevance 0.56 Pain Relevance 0.29
However, TrkB and serpin peptidase inhibitor, clade e (nexin, plasminogen activator inhibitor type 1), member 2 (SERPINE2) were present in the set of 1,663 genes and located in module 1.
Negative_regulation (inhibitor) of TrkB
2) Confidence 0.37 Published 2008 Journal Genome Biol Section Body Doc Link PMC2760875 Disease Relevance 0.61 Pain Relevance 0.59
However, TrkB is downregulated following the binding of BDNF [45].
Negative_regulation (downregulated) of TrkB associated with bdmf
3) Confidence 0.37 Published 2008 Journal Genome Biol Section Body Doc Link PMC2760875 Disease Relevance 0.74 Pain Relevance 0.60
Intra-RVM sequestration of BDNF and knockdown of TrkB by RNA interference attenuate inflammatory pain.
Negative_regulation (knockdown) of TrkB in RVM associated with ipn and rostral ventromedial medulla
4) Confidence 0.11 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16399679 Disease Relevance 0.97 Pain Relevance 1.11

General Comments

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