INT132690

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Context Info
Confidence 0.40
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 1.26
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (CA1) Golgi apparatus (CA1) cytoplasm (CA1)
Anatomy Link Frequency
interneurons 2
CA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dynorphin 8 100.00 Very High Very High Very High
Enkephalin 2 100.00 Very High Very High Very High
agonist 1 97.20 Very High Very High Very High
Opioid 3 96.78 Very High Very High Very High
anticonvulsant 1 89.84 High High
Hippocampus 2 81.92 Quite High
narcan 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Convulsion 5 98.46 Very High Very High Very High
Epilepsy 6 97.68 Very High Very High Very High
Neurodegenerative Disease 1 91.68 High High
Virus Diseases 1 87.04 High High
Borna Disease 1 86.80 High High
Viral Meningitis 2 85.12 High High
Status Epilepticus 1 68.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Kappa opioid (dynorphin) agonists prevented the behavioural and electroencephalographic seizures produced by convulsant compounds, and these effects were associated with an absence of dynorphin from the dentate gyrus granule cell layer and upregulation of enkephalin in CA1 interneurons, thus reproducing a neurochemical marker of epilepsy, namely low dynorphin tone.
Negative_regulation (absence) of Positive_regulation (upregulation) of CA1 in interneurons associated with epilepsy, convulsion, dynorphin, agonist, enkephalin and opioid
1) Confidence 0.40 Published 2006 Journal Brain Section Abstract Doc Link 16399805 Disease Relevance 1.26 Pain Relevance 0.87

General Comments

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