Kappa opioid (dynorphin) agonists prevented the behavioural and electroencephalographic seizures produced by convulsant compounds, and these effects were associated with an absence of dynorphin from the dentate gyrus granule cell layer and upregulation of enkephalin in CA1 interneurons, thus reproducing a neurochemical marker of epilepsy, namely low dynorphin tone.
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1)
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Confidence
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0.40
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Published
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2006
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Journal
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Brain
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Section
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Abstract
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Doc Link
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16399805
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Disease Relevance
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1.26
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Pain Relevance
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0.87
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This test has worked.