INT132690

Context Info Confidence 0.40 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 1.26 Pain Relevance 0.87

lyase activity (CA1) Golgi apparatus (CA1) cytoplasm (CA1)

Anatomy Link Frequency interneurons 2 CA1 (Homo sapiens)

Pain Link Frequency Relevance Heat Dynorphin 8 100.00 Enkephalin 2 100.00 agonist 1 97.20 Opioid 3 96.78 anticonvulsant 1 89.84 Hippocampus 2 81.92 narcan 1 25.00

Disease Link Frequency Relevance Heat Convulsion 5 98.46 Epilepsy 6 97.68 Neurodegenerative Disease 1 91.68 Virus Diseases 1 87.04 Borna Disease 1 86.80 Viral Meningitis 2 85.12 Status Epilepticus 1 68.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Kappa opioid (dynorphin) agonists prevented the behavioural and electroencephalographic seizures produced by convulsant compounds, and these effects were associated with an absence of dynorphin from the dentate gyrus granule cell layer and upregulation of enkephalin in CA1 interneurons, thus reproducing a neurochemical marker of epilepsy, namely low dynorphin tone.

Negative_regulation (absence) of Positive_regulation (upregulation) of CA1 in interneurons associated with epilepsy, convulsion, dynorphin, agonist, enkephalin and opioid

1) Confidence 0.40 Published 2006 Journal Brain Section Abstract Doc Link 16399805 Disease Relevance 1.26 Pain Relevance 0.87

General Comments

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