INT1327

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Context Info
Confidence 0.62
First Reported 1976
Last Reported 2010
Negated 12
Speculated 10
Reported most in Abstract
Documents 45
Total Number 55
Disease Relevance 6.05
Pain Relevance 22.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Trh) plasma membrane (Trh) nucleus (Trh)
cytoplasm (Trh)
Anatomy Link Frequency
nucleus accumbens 9
pituitary 6
median eminence 6
thyroid 4
stomach 4
Trh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 86 100.00 Very High Very High Very High
Opioid 43 100.00 Very High Very High Very High
Morphine 37 100.00 Very High Very High Very High
Enkephalin 36 100.00 Very High Very High Very High
narcan 31 100.00 Very High Very High Very High
Endogenous opioid 14 100.00 Very High Very High Very High
Catecholamine 6 100.00 Very High Very High Very High
Neurotransmitter 13 99.98 Very High Very High Very High
antagonist 59 99.84 Very High Very High Very High
Somatostatin 15 99.82 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pituitary Cancer 15 100.00 Very High Very High Very High
Galactorrhea 10 99.84 Very High Very High Very High
Lung Cancer 16 99.60 Very High Very High Very High
Reprotox - General 1 10 99.36 Very High Very High Very High
Aging 1 98.92 Very High Very High Very High
Hypothyroidism 2 97.64 Very High Very High Very High
Cancer 81 96.68 Very High Very High Very High
Pain 12 96.48 Very High Very High Very High
Depression 3 94.60 High High
Cushing's Syndrome /

Hypercortisolism

1 91.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vitro cocaine (10(-6)-10(-4) M) inhibited the K(+)-stimulated release in a concentration-dependent manner, but had no effect on the basal release of TRH from the striatum and nucleus accumbens of naive rats.
Neg (no) Regulation (effect) of Localization (release) of TRH in nucleus accumbens associated with nucleus accumbens and cocaine
1) Confidence 0.62 Published 1997 Journal Neuropeptides Section Abstract Doc Link 9243522 Disease Relevance 0.14 Pain Relevance 0.63
Effects of morphine on cold-induced TRH release from the median eminence of unanesthetized rats.
Regulation (Effects) of Localization (release) of TRH in median eminence associated with narcan and morphine
2) Confidence 0.62 Published 1986 Journal Life Sci. Section Title Doc Link 3079851 Disease Relevance 0 Pain Relevance 0.66
Effect of endogenous opioid peptides on TRH release from rat stomach in vitro.
Regulation (Effect) of Localization (release) of TRH in stomach associated with narcan and endogenous opioid
3) Confidence 0.62 Published 1989 Journal Endocrinol. Exp. Section Title Doc Link 2565806 Disease Relevance 0 Pain Relevance 0.69
In turn, striatal dopamine levels have also been shown to modulate the release of TRH within the rat striatum [61], [62], with higher levels of dopamine correlating with higher levels of intrastriatal TRH.
Regulation (modulate) of Localization (release) of TRH in striatum associated with dopamine
4) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978093 Disease Relevance 0.52 Pain Relevance 0.24
The influence of depolarizing agents on the release of TRH and histidyl-proline diketopiperazine [C(HP)] from rat hypothalami was examined in vitro.
Spec (examined) Regulation (influence) of Localization (release) of TRH
5) Confidence 0.62 Published 1987 Journal Endocrinology Section Abstract Doc Link 3100287 Disease Relevance 0 Pain Relevance 0
We have developed a fetal rat hypothalamic cell culture system for the study of factors controlling the acute release of TRH.
Regulation (controlling) of Localization (release) of TRH
6) Confidence 0.62 Published 1987 Journal J. Endocrinol. Section Abstract Doc Link 3125299 Disease Relevance 0 Pain Relevance 0
Neither antagonist had an effect on basal TRH release when added alone to the medium.
Regulation (effect) of Localization (release) of TRH associated with antagonist
7) Confidence 0.62 Published 1985 Journal Endocrinology Section Abstract Doc Link 2986944 Disease Relevance 0 Pain Relevance 0.31
Effects of opioid peptides on thyrotropin-releasing hormone release from the rat caecum in vitro.
Regulation (Effects) of Localization (release) of thyrotropin-releasing hormone in caecum associated with opioid
8) Confidence 0.61 Published 1989 Journal Horm. Metab. Res. Section Title Doc Link 2506116 Disease Relevance 0 Pain Relevance 0.69
The aim of this study was to investigate the effect of opioid peptides and depolarizing concentrations of K+ on the release of both vasoactive intestinal polypeptide (VIP) and thyrotropin releasing hormone (TRH) from perifused rat hypothalami.
Spec (investigate) Regulation (effect) of Localization (release) of TRH associated with opioid
9) Confidence 0.61 Published 1987 Journal Life Sci. Section Abstract Doc Link 3102870 Disease Relevance 0 Pain Relevance 0.56
To investigate the role played by hypothalamic noradrenaline (NE) in the regulation of TRH-TSH release during tonic and cold activated conditions, drugs and surgical procedures able to interfere with central NE tonus were utilized.
Regulation (regulation) of Localization (release) of TRH associated with noradrenaline
10) Confidence 0.60 Published 1977 Journal Endocrinology Section Abstract Doc Link 401025 Disease Relevance 0 Pain Relevance 0.24
Such effects could involve altered hypothalamic TRH secretion, a direct effect on TSH production by the thyrotroph, alterations in circulating free thyroid hormone concentrations, or changes in thyroid hormone uptake by the thyrotroph.
Regulation (involve) of Localization (secretion) of TRH in thyroid
11) Confidence 0.60 Published 1996 Journal Exp. Clin. Endocrinol. Diabetes Section Abstract Doc Link 8740939 Disease Relevance 0.08 Pain Relevance 0.13
Such effects could involve altered hypothalamic TRH secretion, a direct effect on TSH production by the thyrotroph, alterations in circulating free thyroid hormone concentrations, or changes in thyroid hormone uptake by the thyrotroph.
Regulation (altered) of Localization (secretion) of TRH in thyroid
12) Confidence 0.60 Published 1996 Journal Exp. Clin. Endocrinol. Diabetes Section Abstract Doc Link 8740939 Disease Relevance 0.08 Pain Relevance 0.13
Systemic capsaicin pretreatment (125 mg/kg sc) reduced the antisecretory effects of luminal acid on both TRH analogue- and pentagastrin-stimulated acid secretion.
Regulation (effects) of Localization (secretion) of TRH associated with qutenza
13) Confidence 0.45 Published 1995 Journal Am. J. Physiol. Section Abstract Doc Link 7864125 Disease Relevance 0 Pain Relevance 0.60
The effect of morphine and leucine enkephalin on basal and K+-induced TRH release by superfused mediobasal hypothalami in rats was investigated in an oxygenated modified Locke medium at 37 degrees C during 10 min.
Spec (investigated) Regulation (effect) of Localization (release) of TRH associated with enkephalin and morphine
14) Confidence 0.45 Published 1983 Journal Neuroendocrinology Section Abstract Doc Link 6412152 Disease Relevance 0 Pain Relevance 0.76
Glass microelectrode recording method was used to investigate the effect of injection of thyrotropin-releasing hormone (TRH) into nucleus accumbens, nucleus amygdalae or nucleus caudatus on unit discharges from pain-excitation neurons (PEN) in nucleus parafascicularis of the thalamus in rats.
Spec (investigate) Regulation (effect) of Spec (investigate) Localization (injection) of TRH in nucleus accumbens associated with pain, nucleus accumbens and thalamus
15) Confidence 0.45 Published 1991 Journal J. Tongji Med. Univ. Section Abstract Doc Link 1819028 Disease Relevance 0.25 Pain Relevance 0.49
Glass microelectrode recording method was used to investigate the effect of injection of thyrotropin-releasing hormone (TRH) into nucleus accumbens, nucleus amygdalae or nucleus caudatus on unit discharges from pain-excitation neurons (PEN) in nucleus parafascicularis of the thalamus in rats.
Spec (investigate) Regulation (effect) of Localization (injection) of thyrotropin-releasing hormone in nucleus accumbens associated with pain, nucleus accumbens and thalamus
16) Confidence 0.45 Published 1991 Journal J. Tongji Med. Univ. Section Abstract Doc Link 1819028 Disease Relevance 0.25 Pain Relevance 0.46
Effects of opioid peptide antisera treatment on the secretion of thyrotropin (TSH) and thyrotropin-releasing hormone (TRH) in rats were studied.
Regulation (Effects) of Localization (secretion) of TRH associated with opioid
17) Confidence 0.45 Published 1993 Journal Horm. Res. Section Abstract Doc Link 8406344 Disease Relevance 0 Pain Relevance 0.40
Effects of opioid peptide antisera treatment on the secretion of thyrotropin (TSH) and thyrotropin-releasing hormone (TRH) in rats were studied.
Regulation (Effects) of Localization (secretion) of thyrotropin-releasing hormone associated with opioid
18) Confidence 0.45 Published 1993 Journal Horm. Res. Section Abstract Doc Link 8406344 Disease Relevance 0 Pain Relevance 0.39
The aim of this study was to investigate the effect of opioid peptides and depolarizing concentrations of K+ on the release of both vasoactive intestinal polypeptide (VIP) and thyrotropin releasing hormone (TRH) from perifused rat hypothalami.
Spec (investigate) Regulation (effect) of Localization (release) of thyrotropin releasing hormone associated with opioid
19) Confidence 0.45 Published 1987 Journal Life Sci. Section Abstract Doc Link 3102870 Disease Relevance 0 Pain Relevance 0.56
Effect of opioid peptides and potassium on the release of vasoactive intestinal polypeptide and thyrotropin releasing hormone from perifused rat hypothalami.
Regulation (Effect) of Localization (release) of thyrotropin releasing hormone associated with opioid
20) Confidence 0.45 Published 1987 Journal Life Sci. Section Title Doc Link 3102870 Disease Relevance 0 Pain Relevance 0.55

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