INT132700

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Context Info
Confidence 0.39
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 4.33
Pain Relevance 3.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Trpc1) protein complex (Trpc1) transmembrane transport (Trpc1)
cytoplasm (Trpc1)
Anatomy Link Frequency
RVM 1
nerves 1
neurons 1
urethra 1
dorsal horn 1
Trpc1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 4 99.98 Very High Very High Very High
dorsal root ganglion 8 99.28 Very High Very High Very High
primary afferent fibers 3 99.26 Very High Very High Very High
Calcitonin gene-related peptide 9 99.20 Very High Very High Very High
Central grey 8 99.00 Very High Very High Very High
qutenza 30 98.58 Very High Very High Very High
Pain 8 98.24 Very High Very High Very High
substance P 9 98.08 Very High Very High Very High
Antinociceptive 2 97.40 Very High Very High Very High
Nicotine 5 97.34 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 3 99.98 Very High Very High Very High
Urological Neuroanatomy 8 99.00 Very High Very High Very High
Ganglion Cysts 10 98.80 Very High Very High Very High
Nociception 8 98.28 Very High Very High Very High
Pain 7 98.24 Very High Very High Very High
Neuropathic Pain 4 98.04 Very High Very High Very High
Diabetes Mellitus 11 97.76 Very High Very High Very High
Pancreatitis 5 97.72 Very High Very High Very High
Stress Incontinence 2 97.72 Very High Very High Very High
Injury 5 96.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The vanilloid moiety of curcumin is considered important for activation of the transient receptor potential vanilloid 1 (TRPV1), which plays an important role in nociception.
Positive_regulation (activation) of transient receptor potential vanilloid 1 associated with nociception
1) Confidence 0.39 Published 2010 Journal J. Dent. Res. Section Abstract Doc Link 20040737 Disease Relevance 0.74 Pain Relevance 0.39
Nicotine stimulates presynaptic nicotinic acetylcholine receptors in perivascular adrenergic nerves and releases unknown transmitter(s) that activate transient receptor potential vanilloid-1 (TRPV1) located on calcitonin gene-related peptide (CGRP)-containing (CGRPergic) nerves, resulting in vasodilation.
Positive_regulation (activate) of transient receptor potential vanilloid-1 in nerves associated with nicotine, increased venous pressure under development and calcitonin gene-related peptide
2) Confidence 0.26 Published 2009 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 19483072 Disease Relevance 0.23 Pain Relevance 0.32
We tested the hypothesis that the excitation of capsaicin-sensitive primary afferent fibers arising from the uterus through the stimulation of transient receptor potential vanilloid 1 (TRPV1) induces cross-organ sensitization on the pelvic-urethra reflex activity.
Positive_regulation (stimulation) of transient receptor potential vanilloid 1 in urethra associated with stress incontinence, qutenza and primary afferent fibers
3) Confidence 0.25 Published 2008 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 18632800 Disease Relevance 0.44 Pain Relevance 0.96
Recently, we reported increased expression and function of transient receptor potential vanilloid 1 (TRPV1) in large dorsal root ganglion (DRG) neurons in diabetic sensory neuropathy.
Positive_regulation (increased) of transient receptor potential vanilloid 1 in neurons associated with ganglion cysts, dorsal root ganglion, diabetes mellitus and neuropathic pain
4) Confidence 0.21 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18182051 Disease Relevance 1.70 Pain Relevance 0.46
In other tissues, inflammation activates transient receptor potential vanilloid 1 (TRPV1) on sensory nerves to liberate CGRP and substance P (SP) in peripheral tissues and the dorsal horn to cause neurogenic inflammation and pain, respectively.
Positive_regulation (activates) of transient receptor potential vanilloid 1 in dorsal horn associated with pain, inflammation, dorsal horn, neurogenic inflammation and substance p
5) Confidence 0.20 Published 2006 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16399878 Disease Relevance 0.77 Pain Relevance 0.84
Activation of transient receptor potential vanilloid-1 (TRPV1) channels in the periaqueductal gray (PAG) activates OFF antinociceptive neurons of the rostral ventromedial medulla (RVM).
Positive_regulation (Activation) of transient receptor potential vanilloid-1 in RVM associated with antinociceptive, central grey and rostral ventromedial medulla
6) Confidence 0.18 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 18077685 Disease Relevance 0.45 Pain Relevance 0.92

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