INT132718

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Context Info
Confidence 0.16
First Reported 2005
Last Reported 2009
Negated 2
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.36
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (PAX5) nucleus (PAX5) DNA binding (PAX5)
PAX5 (Homo sapiens)
Pain Link Frequency Relevance Heat
abdominal pain 1 90.24 High High
Crohn's disease 3 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
backache 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
Osteoarthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypercalcemia 22 99.60 Very High Very High Very High
Gastroesophageal Reflux Disease 1 91.20 High High
Abdominal Pain 1 90.24 High High
Disorder Of Lipid Metabolism 5 77.08 Quite High
Mycobacterial Infection 81 74.00 Quite High
Infection 11 59.44 Quite High
Hypocalcemia 1 42.64 Quite Low
Laboratory Infection 1 33.20 Quite Low
Disease 8 32.64 Quite Low
Sprains And Strains 18 31.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, D-003 (10 mg/day) reduced urinary excretion of tDPD/Cr, a bone resorption marker and did not change serum BSAP, a bone formation marker, while it lowered cholesterol in study patients.
Neg (not) Regulation (change) of BSAP associated with hypercalcemia
1) Confidence 0.16 Published 2005 Journal Int J Clin Pharmacol Res Section Abstract Doc Link 16402634 Disease Relevance 0.71 Pain Relevance 0.09
Inversely, and based on our luciferase reporter gene assays, the loss of the potential PAX5, AHR and ARNT transcription factor binding sites predicted for the IRGM variant ?
Regulation (sites) of PAX5
2) Confidence 0.09 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2735778 Disease Relevance 0.32 Pain Relevance 0
Serum BSAP levels did not change during the first month after dosing, and then gradually decreased in all treatment groups to about 60% below baseline values.
Neg (not) Regulation (change) of BSAP
3) Confidence 0.07 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1924518 Disease Relevance 0.34 Pain Relevance 0

General Comments

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