INT132754

Context Info Confidence 0.39 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.80 Pain Relevance 0.10

nucleoplasm (Wrn) intracellular (Wrn) helicase activity (Wrn) DNA binding (Wrn) nuclease activity (Wrn) nucleolus (Wrn)

Wrn (Mus musculus)

Pain Link Frequency Relevance Heat ischemia 1 69.52 Restless leg syndrome 1 68.72

Disease Link Frequency Relevance Heat Cognitive Disorder 2 97.88 Aging 2 96.68 Cancer 1 95.00 Premature Aging 1 93.20 Werner Syndrome 1 91.68 Myocardial Infarction 1 72.24 Coronary Artery Disease 1 70.40 Increased Venous Pressure Under Development 1 68.72 Stroke 1 64.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

To test this hypothesis, we assessed the impact of the i1-C/T, L1074F and C1367R polymorphisms in the WRN gene on the occurrence of cardiovascular pathologies, on cognitive performance and on the risks of all-cause, cardiovascular and cancer mortalities in the population-based Leiden 85-plus Study.

Regulation (impact) of WRN gene associated with cognitive disorder and cancer

1) Confidence 0.39 Published 2006 Journal Mech. Ageing Dev. Section Abstract Doc Link 16405962 Disease Relevance 0.80 Pain Relevance 0.10

General Comments

This test has worked.