INT13276

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.53
First Reported 1990
Last Reported 2011
Negated 44
Speculated 15
Reported most in Body
Documents 107
Total Number 122
Disease Relevance 30.78
Pain Relevance 69.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spinal 9
amygdala 5
hippocampus 4
synapses 3
dentate gyrus 2
Ltp (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 3843 100.00 Very High Very High Very High
depression 901 100.00 Very High Very High Very High
amygdala 573 100.00 Very High Very High Very High
c fibre 85 100.00 Very High Very High Very High
Hyperalgesia 29 100.00 Very High Very High Very High
Adelta 6 100.00 Very High Very High Very High
central sensitization 2 100.00 Very High Very High Very High
nMDA receptor 829 99.98 Very High Very High Very High
Opioid 29 99.98 Very High Very High Very High
gABA 44 99.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 910 100.00 Very High Very High Very High
Stress 456 100.00 Very High Very High Very High
Hyperalgesia 32 100.00 Very High Very High Very High
Targeted Disruption 820 99.84 Very High Very High Very High
Anaerobic Bacterial Infections 64 99.46 Very High Very High Very High
Aids-related Complex 209 99.36 Very High Very High Very High
Nervous System Injury 35 99.32 Very High Very High Very High
Pain 287 98.66 Very High Very High Very High
Shock 120 98.16 Very High Very High Very High
Hypersensitivity 10 98.14 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been shown that both, stimuli with emotional/motivational content and the electrical stimulation the basolateral amygdala, can modulate hippocampal LTP.
Regulation (modulate) of LTP in amygdala associated with long-term potentiation and amygdala
1) Confidence 0.53 Published 2008 Journal Neuroscience Section Abstract Doc Link 18160226 Disease Relevance 0 Pain Relevance 0.45
The effect on synaptic transmission and on LTP was completely reversed or prevented by application of nor-BNI, which itself had no effect on synaptic transmission or the induction of LTP.
Regulation (effect) of LTP
2) Confidence 0.51 Published 2009 Journal Eur J Pain Section Body Doc Link 18439862 Disease Relevance 0 Pain Relevance 0
In the present study, the maintenance of cingulate LTP was not affected by PD98059, suggesting that the ERK signaling cascade is not persistently activated during LTP in the ACC.
Neg (not) Regulation (affected) of LTP associated with long-term potentiation and anterior cingulate cortex
3) Confidence 0.46 Published 2007 Journal Mol Pain Section Body Doc Link PMC2245920 Disease Relevance 0 Pain Relevance 0.92
Previous studies indicate that LTP of glutamatergic synapses in the lateral amygdala is controlled by GABAA receptor-mediated inhibition (Shumyatsky et al, 2002; Bissiere et al, 2003).
Regulation (controlled) of LTP in amygdala associated with long-term potentiation and amygdala
4) Confidence 0.46 Published 2007 Journal Mol Pain Section Body Doc Link PMC2245920 Disease Relevance 0 Pain Relevance 0.58
Therefore, we examined the effects of MAPK inhibitors on cingulate LTP by postsynaptic injection.
Spec (examined) Regulation (effects) of LTP associated with long-term potentiation
5) Confidence 0.46 Published 2007 Journal Mol Pain Section Body Doc Link PMC2245920 Disease Relevance 0 Pain Relevance 0.51
Thus, it is clearly indicated that the downstream targets of these receptors affected the early-phase LTP in ACC neurons of the CaMKIV transgenic mice.
Regulation (affected) of LTP in ACC neurons associated with targeted disruption, long-term potentiation and anterior cingulate cortex
6) Confidence 0.45 Published 2010 Journal Mol Brain Section Body Doc Link PMC2949850 Disease Relevance 0.40 Pain Relevance 0.56
In the present study, we found that hippocampal CA1 LTD was significantly reduced in TgDREAM mice while hippocampal LTP was not affected.
Neg (not) Regulation (affected) of LTP associated with depression and long-term potentiation
7) Confidence 0.34 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 1.42 Pain Relevance 0.48
Similar LTP was observed in TgDREAM mice (174.6 ± 1.5% of baseline response, n = 6) (Figure 3B and 3C), indicating that LTP is not affected in transgenic mice.
Neg (not) Regulation (affected) of LTP associated with targeted disruption and long-term potentiation
8) Confidence 0.34 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 0.49 Pain Relevance 0.56
Further studies are needed to address the differential modulation of DREAM on hippocampal LTP and LTD.
Regulation (modulation) of LTP associated with depression and long-term potentiation
9) Confidence 0.34 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 0.95 Pain Relevance 0.88
M), in the intracellular solution had no effect on cingulate LTP induced by the pairing protocol (5 ?
Regulation (cingulate) of LTP associated with long-term potentiation
10) Confidence 0.33 Published 2007 Journal Mol Pain Section Body Doc Link PMC2245920 Disease Relevance 0 Pain Relevance 0.53
M) completely blocked the induction of cingulate LTP (15 ?
Regulation (cingulate) of LTP associated with long-term potentiation
11) Confidence 0.33 Published 2007 Journal Mol Pain Section Body Doc Link PMC2245920 Disease Relevance 0 Pain Relevance 0.50
M), in the intracellular solution had no effect on cingulate LTP induced by the pairing protocol (5 ?
Neg (no) Regulation (effect) of LTP associated with long-term potentiation
12) Confidence 0.33 Published 2007 Journal Mol Pain Section Body Doc Link PMC2245920 Disease Relevance 0 Pain Relevance 0.53
Next, we examined the effect of picrotoxin on LTP induced by the EPSP-AP protocol.
Spec (examined) Regulation (effect) of LTP associated with long-term potentiation
13) Confidence 0.33 Published 2007 Journal Mol Pain Section Body Doc Link PMC2245920 Disease Relevance 0 Pain Relevance 0.57
It has been recognised however that relative dendritic location of electrodes could affect the degree of LTP in the hippocampus [29,50,56] and neocortex [57].
Regulation (affect) of LTP in hippocampus associated with hippocampus and long-term potentiation
14) Confidence 0.31 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1574331 Disease Relevance 0.08 Pain Relevance 0.22
(iv) Finally, they show a distinct pattern of action on glutamatergic and GABAergic transmission without affecting LTP.
Neg (without) Regulation (affecting) of LTP associated with gabaergic
15) Confidence 0.31 Published 2001 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 11642654 Disease Relevance 0.15 Pain Relevance 0.30
While norepinephrine had no facilitatory effect on LTP induced in the presence of picrotoxin, the addition of norepinephrine to the external medium allowed the induction of LTP under conditions of intact inhibition when it otherwise would not have occurred.
Neg (no) Regulation (effect) of LTP in external associated with long-term potentiation
16) Confidence 0.30 Published 2010 Journal Mol Brain Section Body Doc Link PMC2877027 Disease Relevance 0.06 Pain Relevance 0.50
A recent work using electroporation of mutant CaM in the ACC suggest that Calcium binding sites of CaM is critical for the induction of cingulate LTP [47].
Regulation (cingulate) of LTP associated with long-term potentiation and anterior cingulate cortex
17) Confidence 0.27 Published 2007 Journal Mol Pain Section Body Doc Link PMC1904186 Disease Relevance 0 Pain Relevance 0.78
Second, since AMPA receptor-mediated EPSC is enhanced in the KO mice, the synaptic responses may have already been saturated and thus affect the following LTP induction.
Spec (may) Regulation (affect) of LTP associated with targeted disruption and long-term potentiation
18) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 1.40 Pain Relevance 0.75
After obtaining stable EPSCs for 10 min, the LTP induction paradigm was used within 12 min after establishing the whole-cell configuration to prevent wash out effect on LTP induction [66].
Regulation (effect) of LTP associated with long-term potentiation
19) Confidence 0.26 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734546 Disease Relevance 0.12 Pain Relevance 0.26
In contrast, in medial perforant path projections to the dentate gyrus and CA3 region, both LTP induction and the maintenance of E- and L-LTP were unaffected by prenatal morphine treatment.
Neg (unaffected) Regulation (unaffected) of L-LTP in medial associated with long-term potentiation and morphine
20) Confidence 0.25 Published 2008 Journal J. Neurophysiol. Section Abstract Doc Link 18199817 Disease Relevance 0.09 Pain Relevance 1.78

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox