INT132760

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Context Info
Confidence 0.66
First Reported 2006
Last Reported 2010
Negated 6
Speculated 1
Reported most in Body
Documents 47
Total Number 48
Disease Relevance 28.17
Pain Relevance 2.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pgr) nucleus (Pgr) enzyme binding (Pgr)
DNA binding (Pgr) cytoplasm (Pgr)
Anatomy Link Frequency
mammary glands 4
endometrium 3
brain 2
lymph nodes 1
epithelial cells 1
Pgr (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 106 99.50 Very High Very High Very High
endometriosis 23 98.20 Very High Very High Very High
Dismenorea 15 97.64 Very High Very High Very High
withdrawal 10 97.56 Very High Very High Very High
Eae 10 96.52 Very High Very High Very High
imagery 36 93.36 High High
cytokine 15 87.52 High High
Inflammatory mediators 12 82.92 Quite High
Inflammatory marker 4 70.24 Quite High
Pain 10 65.68 Quite High
Disease Link Frequency Relevance Heat
Cancer 585 100.00 Very High Very High Very High
Endometrial Cancer 77 99.98 Very High Very High Very High
Targeted Disruption 399 99.88 Very High Very High Very High
Breast Cancer 226 99.84 Very High Very High Very High
Disease 166 99.84 Very High Very High Very High
Nasopharynx Cancer 53 99.84 Very High Very High Very High
Sprains And Strains 983 99.78 Very High Very High Very High
Carcinoma 182 99.58 Very High Very High Very High
INFLAMMATION 134 99.50 Very High Very High Very High
Pre-term Labor 36 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the PR-B expression was significantly reduced in the ectopic endometrium.
Gene_expression (expression) of PR-B in endometrium
1) Confidence 0.66 Published 2006 Journal Epigenetics : official journal of the DNA Methylation Society Section Abstract Doc Link 17965625 Disease Relevance 0.97 Pain Relevance 0.44
Interestingly, PR-B was highly expressed in MPA and progesterone treated BALB/c (P < 0.001 and P < 0.05, respectively) and C57BL/6 mice (P < 0.01; Figure 4b), and followed a similar pattern of expression as ER-?.
Gene_expression (expressed) of PR-B
2) Confidence 0.58 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1868922 Disease Relevance 0.30 Pain Relevance 0
To determine ER and PR expression in reconstituted mammary glands, the same procedures were performed in four untreated Swiss nu/nu mice, BALB/c or C57BL/6 mice.


Spec (determine) Gene_expression (expression) of PR in mammary glands
3) Confidence 0.58 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1868922 Disease Relevance 0 Pain Relevance 0.05
In addition, virgin BALB/c mammary glands expressed higher levels of PR-A and ER-?
Gene_expression (expressed) of PR in mammary glands
4) Confidence 0.58 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1868922 Disease Relevance 0.34 Pain Relevance 0
The expression of ER and PR is regulated by endocrine factors and by extracellular matrix components such as collagen IV or laminin [59].
Gene_expression (expression) of PR in extracellular matrix
5) Confidence 0.58 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1868922 Disease Relevance 0.66 Pain Relevance 0
These tumors are different not only in histology but also in ER, PR, and epidermal growth factor (EGF) receptor expression [24].
Gene_expression (expression) of PR associated with cancer
6) Confidence 0.58 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1868922 Disease Relevance 0.51 Pain Relevance 0
Immunohistochemically, the tumors were estrogen receptor (ER) and progesterone receptor (PgR) positive and C-erbB-2 negative.
Neg (negative) Gene_expression (negative) of progesterone receptor associated with cancer
7) Confidence 0.53 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2292720 Disease Relevance 1.31 Pain Relevance 0
Immunohistochemically, the tumors were estrogen receptor (ER) and progesterone receptor (PgR) positive and C-erbB-2 negative.
Neg (negative) Gene_expression (negative) of PgR associated with cancer
8) Confidence 0.53 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2292720 Disease Relevance 1.30 Pain Relevance 0
Medroxyprogesterone acetate (MPA) induces ductal mammary carcinomas in BALB/c mice that express ER and PR [17,18].
Gene_expression (express) of PR associated with carcinoma
9) Confidence 0.51 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1868922 Disease Relevance 1.48 Pain Relevance 0
Interestingly, most of the genetically modified mice available for the study of breast cancer do not express ER and PR [2], leaving few models available in which to address hormone-dependent tumor progression specifically.
Neg (not) Gene_expression (express) of PR associated with cancer and breast cancer
10) Confidence 0.51 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1868922 Disease Relevance 1.61 Pain Relevance 0
However, this finding according to progesterone receptor status has not been confirmed either in a similar trial comparing letrozole with tamoxifen12 or by the Trans-ATAC investigators who investigated a subset of patients from whom tissue was able to assess a link between quantitative ER and PgR expression and HER2 status with recurrence in the ATAC.13
Gene_expression (expression) of PgR associated with recurrence
11) Confidence 0.51 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2690973 Disease Relevance 0.67 Pain Relevance 0
overexpression, increased PR levels were also observed.
Gene_expression (overexpression) of PR
12) Confidence 0.51 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1868922 Disease Relevance 0.65 Pain Relevance 0
overexpression, increased PR levels were also observed.
Gene_expression (levels) of PR
13) Confidence 0.51 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1868922 Disease Relevance 0.65 Pain Relevance 0
and PR-A expression observed between both strains would even out when epithelial mammary cells from both strains were inoculated in the same host.
Gene_expression (expression) of PR associated with sprains and strains
14) Confidence 0.45 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1868922 Disease Relevance 0.35 Pain Relevance 0
Virgin untreated mice of both strains exhibit almost no PR-B expression, as previously reported [35] (Figures 4b,c).
Neg (no) Gene_expression (expression) of PR-B associated with sprains and strains
15) Confidence 0.45 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1868922 Disease Relevance 0.31 Pain Relevance 0
or PR-A expression were observed.
Gene_expression (expression) of PR
16) Confidence 0.45 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1868922 Disease Relevance 0.66 Pain Relevance 0
Within this experimental setting, we studied the carcinogenic effects of MPA, the morphologic changes in mammary glands that are induced by MPA and progesterone, and the levels of ER and PR expression in MPA-treated and progesterone-treated mammary glands.
Gene_expression (expression) of PR in mammary glands
17) Confidence 0.45 Published 2007 Journal Breast Cancer Res Section Abstract Doc Link PMC1868922 Disease Relevance 0.27 Pain Relevance 0
ER and PR expression in recombined mammary glands in nu/nu mice
Gene_expression (expression) of PR in mammary glands
18) Confidence 0.45 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1868922 Disease Relevance 0.27 Pain Relevance 0
One of the hallmarks of the disease is the expression of estrogen receptor (ER) and progesterone receptor (PR), and it is this expression that ultimately drives prognosis and treatment approaches.
Gene_expression (expression) of progesterone receptor associated with disease
19) Confidence 0.45 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1868922 Disease Relevance 1.00 Pain Relevance 0
One of the hallmarks of the disease is the expression of estrogen receptor (ER) and progesterone receptor (PR), and it is this expression that ultimately drives prognosis and treatment approaches.
Gene_expression (expression) of PR associated with disease
20) Confidence 0.45 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1868922 Disease Relevance 1.05 Pain Relevance 0

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