INT132761

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Context Info
Confidence 0.50
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 3.07
Pain Relevance 1.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pgr) nucleus (Pgr) enzyme binding (Pgr)
DNA binding (Pgr) cytoplasm (Pgr)
Anatomy Link Frequency
endometrium 2
stromal cells 1
epithelium 1
Pgr (Mus musculus)
Pain Link Frequency Relevance Heat
endometriosis 29 99.72 Very High Very High Very High
Dismenorea 6 94.72 High High
Pain 5 88.04 High High
Inflammation 3 69.88 Quite High
pain pelvic 2 55.28 Quite High
cytokine 1 46.64 Quite Low
amygdala 11 5.00 Very Low Very Low Very Low
Nucleus accumbens 8 5.00 Very Low Very Low Very Low
Eae 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometriosis 35 99.72 Very High Very High Very High
Reprotox - General 1 1 94.72 High High
Dysmenorrhea 3 93.64 High High
Pain 5 88.04 High High
Disease 5 77.92 Quite High
INFLAMMATION 5 69.88 Quite High
Sprains And Strains 3 64.88 Quite High
Reprotox - General 3 2 55.28 Quite High
Anxiety Disorder 68 50.00 Quite Low
Necrosis 1 47.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In fact, a general tendency for relative progesterone resistance within eutopic and ectopic endometrium of women with endometriosis and also the downregulation of PR-B, but not PR-A, in endometriosis have been noted.
Negative_regulation (downregulation) of PR-B in endometrium associated with endometriosis
1) Confidence 0.50 Published 2006 Journal Epigenetics : official journal of the DNA Methylation Society Section Abstract Doc Link 17965625 Disease Relevance 0.68 Pain Relevance 0.34
Our finding suggests that progesterone resistance in endometriosis in general and the down regulation of PR-B, but not PR-A, in particular, are a result of promoter hypermethylation of PR-B, but not PR-A.
Negative_regulation (regulation) of PR-B associated with endometriosis
2) Confidence 0.37 Published 2006 Journal Epigenetics : official journal of the DNA Methylation Society Section Abstract Doc Link 17965625 Disease Relevance 0.98 Pain Relevance 0.44
Nuclear p65 immunoreactivity was positively associated with heavier menses, and decreased PR-B and increased nuclear p65 immunoreactivity in ectopic endometrium were statistically significantly associated with the severity of dysmenorrhea in women with adenomyosis.
Negative_regulation (decreased) of PR-B in endometrium associated with dismenorea
3) Confidence 0.06 Published 2009 Journal Fertil. Steril. Section Abstract Doc Link 19296948 Disease Relevance 0.35 Pain Relevance 0.35
The inability of endometriotic stromal cells to produce progesterone-induced paracrine factors that stimulate 17beta-HSD-2 may be due to the lack of PR-B and very low levels of progesterone receptor A (PR-A) observed in vivo in endometriotic tissue.
Negative_regulation (lack) of PR-B in stromal cells associated with endometriosis
4) Confidence 0.06 Published 2006 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 16406281 Disease Relevance 0.91 Pain Relevance 0.40
The Cre coding sequence of the CrePR gene [25], [27] was replaced by that of mammalian Cre with the optimal codon usage in mammals by 2-step PCR using pNCrePR [25] and pCXN-Cre [51].
Negative_regulation (replaced) of CrePR
5) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2613534 Disease Relevance 0.06 Pain Relevance 0
Plasma concentrations of progesterone are high during diestrus and cause a specific down-regulation of progesterone receptor (PGR) protein in the luminal epithelium of pigs on days 10 to 12 of the estrous cycle and pregnancy [8].
Negative_regulation (regulation) of progesterone receptor in epithelium
6) Confidence 0.02 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2876169 Disease Relevance 0.07 Pain Relevance 0.03

General Comments

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