INT132769

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Context Info
Confidence 0.37
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.82
Pain Relevance 2.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

PRS (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 9 99.40 Very High Very High Very High
Pain threshold 3 95.64 Very High Very High Very High
Hyperalgesia 1 92.32 High High
Pain 23 91.76 High High
allodynia 2 90.96 High High
Inflammation 11 88.72 High High
pain pelvic 2 84.08 Quite High
Visceral pain 2 75.00 Quite High
Antinociceptive 1 75.00 Quite High
nud 2 66.72 Quite High
Disease Link Frequency Relevance Heat
Stress 6 100.00 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

6 100.00 Very High Very High Very High
Endometriosis 13 99.40 Very High Very High Very High
Pain 22 95.64 Very High Very High Very High
Hyperalgesia 1 92.32 High High
Disease 20 91.44 High High
Neuropathic Pain 8 90.96 High High
INFLAMMATION 7 88.72 High High
Reprotox - General 3 2 84.08 Quite High
Hypersensitivity 1 84.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A reduction of PRS with IVL in group B was significantly greater than that with saline in group A.
Negative_regulation (reduction) of PRS
1) Confidence 0.37 Published 2009 Journal Masui Section Body Doc Link 19928509 Disease Relevance 0.14 Pain Relevance 0
RESULTS: In group A, PRS decreased significantly with saline and decreased furthermore with IVL.
Negative_regulation (decreased) of PRS
2) Confidence 0.27 Published 2009 Journal Masui Section Body Doc Link 19928509 Disease Relevance 0.16 Pain Relevance 0
RESULTS: In group A, PRS decreased significantly with saline and decreased furthermore with IVL.
Negative_regulation (decreased) of PRS
3) Confidence 0.27 Published 2009 Journal Masui Section Body Doc Link 19928509 Disease Relevance 0.16 Pain Relevance 0
PTs were found to be elevated, whereas PRs were reduced for both hands after isometric exercise.
Negative_regulation (reduced) of PRs
4) Confidence 0.16 Published 2007 Journal J Pain Section Abstract Doc Link 17681886 Disease Relevance 0.62 Pain Relevance 0.77
In addition, linaclotide significantly decreased colonic hypersensitivity in the PRS and WAS models.
Negative_regulation (decreased) of PRS associated with stress
5) Confidence 0.13 Published 2010 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 19706070 Disease Relevance 1.61 Pain Relevance 0.82
The rate of objective response was calculated as the number of PRs and CRs, divided by the number of patients evaluable for response.
Negative_regulation (number) of PRs
6) Confidence 0.03 Published 2009 Journal Marine Drugs Section Body Doc Link PMC2666889 Disease Relevance 0.42 Pain Relevance 0.06
The molecular basis of progesterone resistance in endometriosis may be related to an overall reduction in the levels of progesterone receptors (PRs) and the lack of the PR isoform named progesterone receptor B (PR-B).
Negative_regulation (reduction) of PRs associated with endometriosis
7) Confidence 0.03 Published 2006 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 16406281 Disease Relevance 1.18 Pain Relevance 0.61

General Comments

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