INT13277

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Context Info
Confidence 0.52
First Reported 1991
Last Reported 2011
Negated 32
Speculated 3
Reported most in Body
Documents 83
Total Number 87
Disease Relevance 19.68
Pain Relevance 55.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spinal 10
synapses 6
dorsal horn 6
dentate gyrus 4
pyramidal cells 4
Ltp (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 3134 100.00 Very High Very High Very High
nMDA receptor 836 100.00 Very High Very High Very High
Anterior cingulate cortex 807 100.00 Very High Very High Very High
depression 740 100.00 Very High Very High Very High
amygdala 683 100.00 Very High Very High Very High
Pyramidal cell 225 100.00 Very High Very High Very High
c fibre 158 100.00 Very High Very High Very High
dexamethasone 128 100.00 Very High Very High Very High
Dorsal horn neuron 59 100.00 Very High Very High Very High
Dorsal horn 52 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 743 100.00 Very High Very High Very High
Stress 179 100.00 Very High Very High Very High
Nociception 118 100.00 Very High Very High Very High
Nervous System Injury 24 99.92 Very High Very High Very High
Anaerobic Bacterial Infections 34 99.68 Very High Very High Very High
Targeted Disruption 440 99.48 Very High Very High Very High
Anxiety Disorder 370 98.96 Very High Very High Very High
Hyperalgesia 78 98.92 Very High Very High Very High
Pain 365 98.84 Very High Very High Very High
Cognitive Disorder 121 98.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, our study suggests that the MAPK signaling pathway is involved in the induction of cingulate LTP and plays a critical role in physiological conditions.



Regulation (involved) of Positive_regulation (induction) of LTP associated with long-term potentiation
1) Confidence 0.52 Published 2007 Journal Mol Pain Section Abstract Doc Link PMC2245920 Disease Relevance 0.05 Pain Relevance 0.51
The effect on synaptic transmission and on LTP was completely reversed or prevented by application of nor-BNI, which itself had no effect on synaptic transmission or the induction of LTP.
Neg (no) Regulation (effect) of Positive_regulation (induction) of LTP
2) Confidence 0.51 Published 2009 Journal Eur J Pain Section Body Doc Link 18439862 Disease Relevance 0 Pain Relevance 0
However, until now it was unclear whether SK channel function could be modulated to regulate the induction of LTP.
Regulation (modulated) of Positive_regulation (induction) of LTP associated with long-term potentiation
3) Confidence 0.36 Published 2010 Journal Neuron Section Body Doc Link PMC3003154 Disease Relevance 0 Pain Relevance 0.46
Therefore, our data support the conclusion that SK channels can regulate the induction of LTP and provide evidence that SK channel function is controlled by activation of M1 receptors.
Regulation (regulate) of Positive_regulation (induction) of LTP associated with long-term potentiation
4) Confidence 0.36 Published 2010 Journal Neuron Section Body Doc Link PMC3003154 Disease Relevance 0 Pain Relevance 0.36
To test the possibility that the deletion of GluA1 subunit affect the induction of LTP by inhibiting NMDA receptor-mediated currents, we first examined the NMDA receptor-mediated EPSCs evoked by various stimulus intensities.
Regulation (affect) of Positive_regulation (induction) of LTP associated with nmda receptor and long-term potentiation
5) Confidence 0.36 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734546 Disease Relevance 0 Pain Relevance 0.60
As shown in Fig. 7A, capsaicin caused a significant enhancement of the magnitude of EC-induced LA-LTP in the isoflurane group (control: 128.1±4.1% [n?
Regulation (control) of Positive_regulation (induced) of LTP associated with qutenza, isoflurane, long-term potentiation and amygdala
6) Confidence 0.35 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020947 Disease Relevance 0.07 Pain Relevance 1.68
Whereas basal transmission in the LA in horizontal slices is dependent on AMPA and kainate receptors [32]–[34], we could demonstrate that LTP induction in horizontal slices depends on NMDA receptors for both used inputs [32].
Regulation (depends) of Positive_regulation (induction) of LTP associated with nmda receptor, long-term potentiation and amygdala
7) Confidence 0.35 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020947 Disease Relevance 0 Pain Relevance 0.97
In the ACC, bath application of a NMDA receptor antagonist AP-5 completely abolished the induction of LTP induced by different induction protocols in the pyramidal cells [16], indicting that the induction of ACC LTP is completely dependent of postsynaptic activation of NMDA receptors.


Regulation (dependent) of Positive_regulation (induction) of LTP in pyramidal cells associated with nmda receptor antagonist, nmda receptor, pyramidal cell, long-term potentiation and anterior cingulate cortex
8) Confidence 0.33 Published 2009 Journal Mol Brain Section Body Doc Link PMC2644299 Disease Relevance 0 Pain Relevance 1.22
Then we tested the effects of JNK or p38 inhibitor on the induction of cingulate LTP, because the MAPK signaling pathways include extracellular signal-regulated (ERK), c-Jun N-terminal kinase (JNK), p38 and ERK5 [17].
Regulation (effects) of Positive_regulation (induction) of LTP associated with long-term potentiation
9) Confidence 0.33 Published 2007 Journal Mol Pain Section Body Doc Link PMC2245920 Disease Relevance 0 Pain Relevance 0.30
M), in the intracellular solution had no effect on cingulate LTP induced by the pairing protocol (5 ?
Regulation (cingulate) of Positive_regulation (induced) of LTP associated with long-term potentiation
10) Confidence 0.33 Published 2007 Journal Mol Pain Section Body Doc Link PMC2245920 Disease Relevance 0 Pain Relevance 0.53
In contrast to the application before the induction, we found no significant effect on the maintenance of LTP during the 20 min treatment with PD98059 or U0126 (PD98059, 156.5 ± 9.0 % at 30 min after the pairing protocol, 20 min after PD98059 treatment, n = 7, P < 0.05 compared with baseline response, Fig. 8A; U0126, 152.9 ± 5.7 % at 30 min after the pairing protocol, 20 min after U0126 treatment, n = 5, P < 0.05 compared with baseline response, Fig. 8B).
Neg (no) Regulation (effect) of Positive_regulation (maintenance) of LTP associated with long-term potentiation
11) Confidence 0.33 Published 2007 Journal Mol Pain Section Body Doc Link PMC2245920 Disease Relevance 0 Pain Relevance 0.36
M), in the intracellular solution had no effect on cingulate LTP induced by the pairing protocol (5 ?
Neg (no) Regulation (effect) of Positive_regulation (induced) of LTP associated with long-term potentiation
12) Confidence 0.33 Published 2007 Journal Mol Pain Section Body Doc Link PMC2245920 Disease Relevance 0 Pain Relevance 0.53
Considering that late-phase LTP was disrupted by application of protein synthesis inhibitors before and during LTP induction while their application after LTP induction had no effect on its maintenance [9], the late-phase LTP would be necessary for a transient but not persistent upregulation of protein synthesis.
Neg (no) Regulation (effect) of Positive_regulation (induction) of LTP associated with long-term potentiation
13) Confidence 0.33 Published 2010 Journal Mol Brain Section Body Doc Link PMC2949850 Disease Relevance 0.10 Pain Relevance 0.78
Similarly, thresholds for induction of PS LTP were elevated relative to controls in the PL and WL groups, but were not affected by Pb exposure limited to the lactational period (PW).
Neg (not) Regulation (affected) of Positive_regulation (induction) of LTP associated with long-term potentiation
14) Confidence 0.31 Published 1999 Journal Neurotoxicology Section Abstract Doc Link 10091859 Disease Relevance 0 Pain Relevance 0.49
In the ACC, bath application of a NMDA receptor antagonist AP-5 completely abolished the induction of LTP induced by different induction protocols in the pyramidal cells [16], indicting that the induction of ACC LTP is completely dependent of postsynaptic activation of NMDA receptors.


Regulation (dependent) of Positive_regulation (induction) of LTP in pyramidal cells associated with nmda receptor antagonist, nmda receptor, pyramidal cell, long-term potentiation and anterior cingulate cortex
15) Confidence 0.29 Published 2009 Journal Mol Brain Section Body Doc Link PMC2644299 Disease Relevance 0 Pain Relevance 1.30
A recent work using electroporation of mutant CaM in the ACC suggest that Calcium binding sites of CaM is critical for the induction of cingulate LTP [47].
Regulation (cingulate) of Positive_regulation (induction) of LTP associated with long-term potentiation and anterior cingulate cortex
16) Confidence 0.27 Published 2007 Journal Mol Pain Section Body Doc Link PMC1904186 Disease Relevance 0 Pain Relevance 0.78
In the ACC, the induction of LTP by different protocols is mostly NMDA receptor dependent.
Regulation (dependent) of Positive_regulation (induction) of LTP associated with nmda receptor, long-term potentiation and anterior cingulate cortex
17) Confidence 0.27 Published 2007 Journal Mol Pain Section Body Doc Link PMC1904186 Disease Relevance 0.37 Pain Relevance 1.18
Next, we examined whether pre-conditioning with LTD induction could rescue following LTP induction in neurabin KO mice.
Regulation (rescue) of Positive_regulation (induction) of LTP associated with targeted disruption, depression and long-term potentiation
18) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 0.90 Pain Relevance 0.52
The role of MAPK cascade in the induction of cingulate LTP has been documented in a previous study [14], which showed that activation of MAPK including ERK, JNK and p38 is critical for the induction of cingulate LTP.
Regulation (role) of Positive_regulation (induction) of LTP associated with long-term potentiation
19) Confidence 0.26 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734546 Disease Relevance 0 Pain Relevance 0.64
After obtaining stable EPSCs for 10 min, the LTP induction paradigm was used within 12 min after establishing the whole-cell configuration to prevent wash out effect on LTP induction [66].
Regulation (effect) of Positive_regulation (induction) of LTP associated with long-term potentiation
20) Confidence 0.26 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734546 Disease Relevance 0.12 Pain Relevance 0.26

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