INT132773

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Context Info
Confidence 0.41
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.55
Pain Relevance 2.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Acvr2b) plasma membrane (Acvr2b) kinase activity (Acvr2b)
cytoplasm (Acvr2b)
Anatomy Link Frequency
nerve 2
Acvr2b (Mus musculus)
Pain Link Frequency Relevance Heat
bradykinin 22 99.96 Very High Very High Very High
cINOD 10 98.74 Very High Very High Very High
Analgesic 6 98.62 Very High Very High Very High
Pain 4 98.62 Very High Very High Very High
substance P 2 91.44 High High
analgesia 4 88.44 High High
agonist 4 88.40 High High
algogenic 2 81.60 Quite High
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nociception 18 99.64 Very High Very High Very High
INFLAMMATION 2 95.92 Very High Very High Very High
Hyperinsulinism 1 56.72 Quite High
Targeted Disruption 5 5.00 Very Low Very Low Very Low
Hypertrophy 2 5.00 Very Low Very Low Very Low
Aging 1 5.00 Very Low Very Low Very Low
Confusion 1 5.00 Very Low Very Low Very Low
Muscular Atrophy 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also examined our database of expression profiles of 10 men and 9 women with facioscapulohumeral dystrophy [25] for a sex difference in expression of GRB10 and ACVR2B.
Negative_regulation (difference) of ACVR2B
1) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2148100 Disease Relevance 0.06 Pain Relevance 0
NSAID zaltoprofen possesses novel anti-nociceptive mechanism through blockage of B2-type bradykinin receptor in nerve endings.
Negative_regulation (blockage) of B2-type in nerve associated with nociception, cinod and bradykinin
2) Confidence 0.23 Published 2006 Journal Neurosci. Lett. Section Title Doc Link 16406342 Disease Relevance 0.70 Pain Relevance 1.67
All these results suggest that NSAID zaltoprofen possesses novel anti-nociceptive mechanism, which inhibits B2-type BK receptor function in nerve endings.
Negative_regulation (inhibits) of B2-type in nerve associated with nociception, cinod and bradykinin
3) Confidence 0.23 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16406342 Disease Relevance 0.80 Pain Relevance 1.20

General Comments

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