INT132781

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Context Info
Confidence 0.52
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.83
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PIK3CG) plasma membrane (PIK3CG) cytoplasm (PIK3CG)
Anatomy Link Frequency
Hair 1
skin 1
Fibroblast 1
HT-1080 1
PIK3CG (Homo sapiens)
Pain Link Frequency Relevance Heat
Pyramidal cell 2 93.88 High High
positron emission tomography 8 87.52 High High
Opioid 4 86.96 High High
Inflammation 23 79.60 Quite High
cytokine 17 78.56 Quite High
Eae 12 27.36 Quite Low
Hippocampus 14 5.00 Very Low Very Low Very Low
long-term potentiation 10 5.00 Very Low Very Low Very Low
Kinase C 10 5.00 Very Low Very Low Very Low
Neurotransmitter 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 136 99.46 Very High Very High Very High
Fibrosarcoma 3 97.80 Very High Very High Very High
Apoptosis 272 97.68 Very High Very High Very High
Hyperplasia 3 97.12 Very High Very High Very High
Disease 333 96.60 Very High Very High Very High
Breast Cancer 46 90.72 High High
Adenocarcinoma 3 88.24 High High
Carcinoma 6 85.12 High High
Hepatocellular Cancer 3 81.36 Quite High
Stress 64 79.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hair, skin, and tumor biopsies showed decreased phosphorylation of many products downstream from the PI3K/mTOR pathway inhibited by XL765.
Phosphorylation (phosphorylation) of PI3K in skin associated with cancer
1) Confidence 0.52 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2647552 Disease Relevance 0.55 Pain Relevance 0.04
Hair, skin, and tumor biopsies showed decreased phosphorylation of many products downstream from the PI3K/mTOR pathway inhibited by XL765.
Phosphorylation (phosphorylation) of PI3K in Hair associated with cancer
2) Confidence 0.18 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2647552 Disease Relevance 0.55 Pain Relevance 0.04
Recent study clearly confirmed that almost one dozen of factors such as SHP-1, Grd2, Grb2, phosphatidylinositol 3-OH kinase (PI3K), have also binding abilities to CagA phosphorylation sites [34].
Phosphorylation (phosphorylation) of PI3K
3) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2768901 Disease Relevance 0.28 Pain Relevance 0
Moreover the antitumor effect of another flavonoid, nobiletin, on human fibrosarcoma HT-1080 cells (28) was associated with the inhibition of MEK1/2 activity without influencing the activity of PI3K or the phosphorylation of Akt.
Phosphorylation (phosphorylation) of PI3K in HT-1080 associated with fibrosarcoma
4) Confidence 0.10 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1513146 Disease Relevance 0.32 Pain Relevance 0
After receptor dimeri-zation, an activation cascade of multiple protein kinase activity and tyrosine autophosphorylation occurs, phos-phorylating several intracellular substrates including Ras-Raf-mitogen-activated protein kinase, phosphatidylinositol-3-kinase (PI3K)-Akt, and other important signaling that regulates apoptosis and cellular proliferation pathways [29,30].
Phosphorylation (phorylating) of phosphatidylinositol-3-kinase associated with apoptosis and hyperplasia
5) Confidence 0.09 Published 2010 Journal Breast Cancer Res Section Body Doc Link PMC2972555 Disease Relevance 0.73 Pain Relevance 0
following phosphorylation (and inactivation) by either a PI3K/Akt signaling or the mitogenic Wnt pathway that is a central element of IGF-1 signaling.
Phosphorylation (phosphorylation) of PI3K
6) Confidence 0.09 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 1.20 Pain Relevance 0.05
is phosphorylated (and inactivated) through a PI3K/Akt signaling pathway induced by IGF-1, NGF and any growth factor whose activity is mediated by receptors with intrinsic tyrosine kinase activity [201], including also Fibroblast Growth Factor-2 (FGF-2).
Phosphorylation (phosphorylated) of PI3K in Fibroblast
7) Confidence 0.09 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.84 Pain Relevance 0
Also, the signaling defects including an attenuated p85 regulatory subunit of phosphatidylinositol 3-kinase (PI3-kinase) and Akt serine phosphorylation were observed.
Phosphorylation (phosphorylation) of phosphatidylinositol 3-kinase
8) Confidence 0.02 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16406665 Disease Relevance 0.37 Pain Relevance 0.40

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