INT132792

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Context Info
Confidence 0.28
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.81
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL4, IL6) extracellular region (IL4, IL6) aging (IL6)
Anatomy Link Frequency
monocyte 1
capillary 1
IL4 (Homo sapiens)
IL6 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 27 97.44 Very High Very High Very High
chemokine 3 95.24 Very High Very High Very High
Opioid 3 92.32 High High
interstitial cystitis 2 84.48 Quite High
Inflammation 9 65.92 Quite High
ischemia 1 62.32 Quite High
antagonist 7 44.24 Quite Low
Inflammatory response 1 18.08 Low Low
corticosteroid 3 5.00 Very Low Very Low Very Low
Enkephalin 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 11 100.00 Very High Very High Very High
Necrosis 5 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 1 92.32 High High
Adhesions 2 90.76 High High
Sepsis 92 88.08 High High
Overactive Bladder 4 87.40 High High
Interstitial Cystitis 2 84.48 Quite High
Vasoplegia 2 83.80 Quite High
Apoptosis 6 81.44 Quite High
INFLAMMATION 15 65.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-4 and IL-13 given separately stimulated MCP-1, IL-6 and SCF secretion in a concentration (0.01 to 100 ng/ml) and time (0 to 24 hours) dependent manner.
IL-4 Positive_regulation (stimulated) of IL-6
1) Confidence 0.28 Published 2006 Journal J. Urol. Section Body Doc Link 16407046 Disease Relevance 0.13 Pain Relevance 0
We investigated whether HDSMCs are capable of expressing and releasing MCP-1, IL-6 and SCF in response to IL-4, IL-13, IL-1beta and tumor necrosis factor-alpha.
IL-4 Positive_regulation (response) of IL-6 associated with necrosis and cancer
2) Confidence 0.12 Published 2006 Journal J. Urol. Section Abstract Doc Link 16407046 Disease Relevance 0.60 Pain Relevance 0.08
These include the release of IL-1, IL-2, IL-4, IL-6, IL-8, IL-10, tumor necrosis factor-alfa (TNF-alfa), platelet-activating factor, endorphins, nitric oxide, reactive oxygen species, tissue factor, macrophage migration inhibitory factor, and chemokines, which lead to a variety of immune system responses including vasodilatation, enhanced expression of adhesion molecules, increased capillary permeability, increased clot formation, and decreased fibrinolysis.
IL-4 Positive_regulation (activating) of IL-6 in capillary associated with chemokine, necrosis, cancer, increased venous pressure under development and adhesions
3) Confidence 0.04 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012437 Disease Relevance 0.99 Pain Relevance 0.16
The action of melatonin on monocyte production can be partly due to its direct action on melatonin receptors or may be due to an increase of monocyte sensitivity to stimulants like IL-3, IL-4, IL-6 or GM-colony stimulating factor (GM-CSF) [88-90].
IL-4 Positive_regulation (stimulants) of IL-6 in monocyte
4) Confidence 0.02 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1325257 Disease Relevance 0.09 Pain Relevance 0.23

General Comments

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