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Context Info
Confidence 0.26
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.47
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL4, IL6) extracellular region (IL4, IL6) aging (IL6)
Anatomy Link Frequency
capillary 2
smooth muscle cells 2
IL4 (Homo sapiens)
IL6 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 7 98.36 Very High Very High Very High
chemokine 1 95.24 Very High Very High Very High
interstitial cystitis 1 94.92 High High
Inflammation 5 65.92 Quite High
ischemia 1 62.32 Quite High
antagonist 6 44.24 Quite Low
Inflammatory response 1 19.00 Low Low
corticosteroid 3 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
dexamethasone 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Necrosis 3 100.00 Very High Very High Very High
Cancer 3 100.00 Very High Very High Very High
Overactive Bladder 2 98.68 Very High Very High Very High
Interstitial Cystitis 1 94.92 High High
Increased Venous Pressure Under Development 1 92.32 High High
Adhesions 1 90.76 High High
Sepsis 92 89.00 High High
Vasoplegia 2 84.72 Quite High
Apoptosis 3 82.36 Quite High
INFLAMMATION 11 65.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interleukin-4 and 13 induce the expression and release of monocyte chemoattractant protein 1, interleukin-6 and stem cell factor from human detrusor smooth muscle cells: synergy with interleukin-1beta and tumor necrosis factor-alpha.
Interleukin-4 Positive_regulation (induce) of Localization (release) of interleukin-6 in smooth muscle cells associated with necrosis, cancer and overactive bladder
1) Confidence 0.26 Published 2006 Journal J. Urol. Section Title Doc Link 16407046 Disease Relevance 0.48 Pain Relevance 0.09
These include the release of IL-1, IL-2, IL-4, IL-6, IL-8, IL-10, tumor necrosis factor-alfa (TNF-alfa), platelet-activating factor, endorphins, nitric oxide, reactive oxygen species, tissue factor, macrophage migration inhibitory factor, and chemokines, which lead to a variety of immune system responses including vasodilatation, enhanced expression of adhesion molecules, increased capillary permeability, increased clot formation, and decreased fibrinolysis.
IL-4 Positive_regulation (activating) of Localization (release) of IL-6 in capillary associated with chemokine, necrosis, cancer, increased venous pressure under development and adhesions
2) Confidence 0.04 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012437 Disease Relevance 0.99 Pain Relevance 0.16

General Comments

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