INT132822

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Context Info
Confidence 0.67
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 26
Total Number 27
Disease Relevance 22.85
Pain Relevance 6.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IL13) extracellular space (IL13) extracellular region (IL13)
cell-cell signaling (IL13) cytoplasm (IL13)
Anatomy Link Frequency
Th2 cells 3
B cells 2
mast cells 2
nasal 1
eosinophils 1
IL13 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 696 100.00 Very High Very High Very High
Inflammation 443 99.36 Very High Very High Very High
Inflammatory mediators 15 99.24 Very High Very High Very High
corticosteroid 117 95.68 Very High Very High Very High
agonist 88 94.80 High High
chemokine 62 88.84 High High
qutenza 10 82.56 Quite High
Inflammatory response 33 75.04 Quite High
antagonist 86 72.12 Quite High
Crohn's disease 5 71.52 Quite High
Disease Link Frequency Relevance Heat
Cancer 420 99.86 Very High Very High Very High
Asthma 1106 99.84 Very High Very High Very High
INFLAMMATION 490 99.36 Very High Very High Very High
Nicotine Addiction 272 99.24 Very High Very High Very High
Rhinitis 44 99.20 Very High Very High Very High
Hypersensitivity 147 98.56 Very High Very High Very High
Mastocytosis 3 97.52 Very High Very High Very High
Autoimmune Disease 77 96.76 Very High Very High Very High
Disease 368 96.56 Very High Very High Very High
Aging 61 95.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
and Th2 (IL13) cytokine secretion.
Localization (secretion) of IL13 associated with cytokine
1) Confidence 0.67 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605261 Disease Relevance 0.09 Pain Relevance 0.09
and Th2 (IL-5 and IL-13) cytokines increased in all study groups, with a predominant secretion of IL13, even in absence of aluminium adjuvant (figure 2).
Localization (secretion) of IL13 associated with cytokine
2) Confidence 0.63 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605261 Disease Relevance 0.34 Pain Relevance 0.09
T helper-2 (TH-2) lymphocytes release cytokines, including IL-4, IL-5 and IL-13, that have a range of actions, including eosinophil activation and immunoglobulin secretion from B cells.
Localization (release) of IL-13 in B cells associated with cytokine
3) Confidence 0.58 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2820465 Disease Relevance 1.06 Pain Relevance 0.45
IL-4 and IL-13 given separately stimulated MCP-1, IL-6 and SCF secretion in a concentration (0.01 to 100 ng/ml) and time (0 to 24 hours) dependent manner.
Localization (secretion) of IL-13
4) Confidence 0.41 Published 2006 Journal J. Urol. Section Body Doc Link 16407046 Disease Relevance 0.13 Pain Relevance 0
IgE formation is stimulated by the release of interleukin 4 (IL-4) and interleukin 13 (IL-13) produced by several cell types including a subset of T-helper lymphocytes prevalent in atopy called Th2 cells (Guachat et al. 1990; de Vries et al. 1999).
Localization (release) of interleukin 13 in Th2 cells associated with asthma
5) Confidence 0.39 Published 2008 Journal Core Evidence Section Body Doc Link PMC2899803 Disease Relevance 1.28 Pain Relevance 0.15
IgE formation is stimulated by the release of interleukin 4 (IL-4) and interleukin 13 (IL-13) produced by several cell types including a subset of T-helper lymphocytes prevalent in atopy called Th2 cells (Guachat et al. 1990; de Vries et al. 1999).
Localization (release) of IL-13 in Th2 cells associated with asthma
6) Confidence 0.39 Published 2008 Journal Core Evidence Section Body Doc Link PMC2899803 Disease Relevance 1.28 Pain Relevance 0.15
Measurements of IL-13 in secretions might be taken into account as a noninvasive marker of airway inflammation and to assess the detrimental effects of ETS.
Localization (secretions) of IL-13 associated with nicotine addiction and inflammation
7) Confidence 0.36 Published 2007 Journal Cough Section Body Doc Link PMC1884172 Disease Relevance 1.79 Pain Relevance 0.28
As an example, IL13 is important in the pathogenesis of asthma and there is interest to explore its use as a systemic disease biomarker of asthma as well as a PD biomarker for therapeutics targeting IL13 (St Ledger et al., 2009).
Localization (important) of IL13 associated with asthma and disease
8) Confidence 0.35 Published 2010 Journal Toxicological Sciences Section Body Doc Link PMC2923281 Disease Relevance 0.56 Pain Relevance 0.24
Together, these results indicate that ETS exposure augments the expression and secretion of IL-13 in allergic asthma.
Localization (secretion) of IL-13 associated with asthma and nicotine addiction
9) Confidence 0.34 Published 2007 Journal Cough Section Body Doc Link PMC1884172 Disease Relevance 1.77 Pain Relevance 0.27
Parental tobacco smoking lead to a significant increase in airway IL-13 secretion compared with nonexposed children and healthy control subjects (median, 860 pg/mL vs 242 pg/mL and 125 pg/mL, respectively) [74].
Localization (secretion) of IL-13 associated with nicotine addiction
10) Confidence 0.34 Published 2007 Journal Cough Section Body Doc Link PMC1884172 Disease Relevance 1.75 Pain Relevance 0.21
These events ultimately lead to the release of important cytokines such as IL-4 and IL-13 critical for immunoglobulin E (IgE) production.
Localization (release) of IL-13 associated with cytokine
11) Confidence 0.33 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946700 Disease Relevance 0.69 Pain Relevance 0.32
Important in this process is the release of more IL-4 and IL-13 from a number of different inflammatory cells including mast cells, as well as IL-9.
Localization (release) of IL-13 in mast cells associated with inflammation
12) Confidence 0.33 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946700 Disease Relevance 0.72 Pain Relevance 0.29
Cytokine secretion (interleukin (IL) 5 and IL13 as surrogate markers of a Th2 response, and interferon gamma (IFN?)
Localization (secretion) of IL13 associated with cytokine
13) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605261 Disease Relevance 0.55 Pain Relevance 0.20
Type 2 response is related to secretion of IL-4, IL-5, IL-9 and IL-13 which promote induction of IgE and allergic response.
Localization (secretion) of IL-13 associated with hypersensitivity
14) Confidence 0.21 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2848054 Disease Relevance 0.99 Pain Relevance 0.41
These goblet cells were induced by IL-13 secreted by Th2 cells [81].
Localization (secreted) of IL-13 in Th2 cells
15) Confidence 0.15 Published 2006 Journal Clin Mol Allergy Section Body Doc Link PMC1538622 Disease Relevance 0.98 Pain Relevance 0.04
In a second phase, cortisol enhances the recruitment of T-helper-2 cells, and subsequently released cytokines such as IL-2, IL-4 and IL-13 stimulate 11?
Localization (released) of IL-13 associated with cytokine
16) Confidence 0.14 Published 2004 Journal Crit Care Section Body Doc Link PMC522845 Disease Relevance 0.48 Pain Relevance 0.29
These data support the potential utility of a dual IL-4 and IL-13 oligonucleotide inhibitor in asthma, and suggest that local inhibition of IL-4R?
Localization (utility) of IL-13 associated with asthma
17) Confidence 0.13 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 1.00 Pain Relevance 0.22
Interestingly, the treatment of children with allergic rhinitis with montelukast induces a significant decrease of nasal lavage IL-4 and IL-13 and a significant increase of IFN-?
Localization (decrease) of IL-13 in nasal associated with rhinitis
18) Confidence 0.13 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.87 Pain Relevance 0.41
The secreted IL-13 signals cancer cells as demonstrated by the presence of phosphorylated STAT-6 and contributes to tumor growth as demonstrated in humanized mice model described hereunder [8] (K Palucka, Baylor Institute for Immunology Research, TX).
Localization (secreted) of IL-13 associated with cancer and general immunology
19) Confidence 0.11 Published 2007 Journal J Transl Med Section Body Doc Link PMC2176053 Disease Relevance 1.44 Pain Relevance 0.09
Th2 responses are mediated through the secretion of a different set of cytokines, primarily interleukin-1, interleukin-4, interleukin-6, interleukin-10, and interleukin-13, and B cells, eosinophils, and mast cells [11].
Localization (secretion) of interleukin-13 in eosinophils associated with cytokine
20) Confidence 0.06 Published 2009 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2723676 Disease Relevance 0.91 Pain Relevance 0.39

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