INT132833

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Context Info
Confidence 0.55
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 10
Disease Relevance 3.10
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Hcrt) cytoplasm (Hcrt)
Anatomy Link Frequency
nucleus accumbens 2
Hcrt (Mus musculus)
Pain Link Frequency Relevance Heat
Nucleus accumbens 1 99.70 Very High Very High Very High
Ventral tegmentum 5 99.08 Very High Very High Very High
Dopamine 16 98.68 Very High Very High Very High
Morphine 6 96.40 Very High Very High Very High
agonist 1 90.60 High High
opioid receptor 1 90.28 High High
nMDA receptor 2 82.76 Quite High
antagonist 1 80.88 Quite High
Locus ceruleus 86 40.24 Quite Low
gABA 112 34.40 Quite Low
Disease Link Frequency Relevance Heat
Death 20 99.00 Very High Very High Very High
Targeted Disruption 191 92.08 High High
Injury 2 83.40 Quite High
Overdose 28 78.32 Quite High
Sleep Disorders 418 75.76 Quite High
Apoptosis 8 72.08 Quite High
Vibrio Infection 14 70.76 Quite High
Disease 15 69.60 Quite High
Sprains And Strains 115 62.08 Quite High
Cancer 6 46.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The lack of effects of IGFBP3 on cell death in this model might be due to the differences in circulating vs hypocretin cell specific IGFBP3 overexpression, or to lack of an IGFBP3 effect in the context of ataxin-induced cell degeneration, but is consistent with the notion that IGFBP3 may be proapoptotic only in specific circumstances, such as cancerous cells.
Positive_regulation (overexpression) of Gene_expression (overexpression) of hypocretin associated with death
1) Confidence 0.55 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.98 Pain Relevance 0.04
Mice (20–35 g) homozygous with respect to the deletion of the hypocretin gene on both alleles (HCRT-ko n?
Positive_regulation (homozygous) of Gene_expression (deletion) of hypocretin
2) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.27 Pain Relevance 0
The levels of dopamine and its major metabolites in the nucleus accumbens were markedly increased by the microinjection of orexin A and orexin B into the VTA.
Positive_regulation (increased) of Gene_expression (microinjection) of orexin A in nucleus accumbens associated with ventral tegmentum, nucleus accumbens and dopamine
3) Confidence 0.49 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16407535 Disease Relevance 0 Pain Relevance 0.93
Following this reaction, one of these wells was then processed for a second reaction with hypocretin (rabbit anti HCRT sc8070, 1?
Positive_regulation (Following) of Gene_expression (rabbit) of HCRT
4) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.15 Pain Relevance 0
Following this reaction, one of these wells was then processed for a second reaction with hypocretin (rabbit anti HCRT sc8070, 1?
Positive_regulation (anti) of Gene_expression (rabbit) of HCRT
5) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.14 Pain Relevance 0
Following this reaction, one of these wells was then processed for a second reaction with hypocretin (rabbit anti HCRT sc8070, 1?
Positive_regulation (anti) of Gene_expression (sc8070) of HCRT
6) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.14 Pain Relevance 0
Following this reaction, one of these wells was then processed for a second reaction with hypocretin (rabbit anti HCRT sc8070, 1?
Positive_regulation (Following) of Gene_expression (rabbit) of hypocretin
7) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.15 Pain Relevance 0
Following this reaction, one of these wells was then processed for a second reaction with hypocretin (rabbit anti HCRT sc8070, 1?
Positive_regulation (anti) of Gene_expression (rabbit) of hypocretin
8) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.14 Pain Relevance 0
Following this reaction, one of these wells was then processed for a second reaction with hypocretin (rabbit anti HCRT sc8070, 1?
Positive_regulation (Following) of Gene_expression (sc8070) of HCRT
9) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.15 Pain Relevance 0
The lack of effects of IGFBP3 on cell death in this model might be due to the differences in circulating vs hypocretin cell specific IGFBP3 overexpression, or to lack of an IGFBP3 effect in the context of ataxin-induced cell degeneration, but is consistent with the notion that IGFBP3 may be proapoptotic only in specific circumstances, such as cancerous cells.
Positive_regulation (circulating) of Gene_expression (overexpression) of hypocretin associated with death
10) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2617764 Disease Relevance 0.98 Pain Relevance 0.04

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