INT132836

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Context Info
Confidence 0.30
First Reported 2004
Last Reported 2006
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.42
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Csk) plasma membrane (Csk) kinase activity (Csk)
cytoplasm (Csk)
Anatomy Link Frequency
osteoclasts 1
Csk (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 6 94.56 High High
Intracerebroventricular 1 88.08 High High
Arthritis 40 76.32 Quite High
cytokine 18 66.80 Quite High
Nucleus accumbens 3 66.08 Quite High
Inflammation 19 53.72 Quite High
rheumatoid arthritis 36 44.96 Quite Low
Osteoarthritis 11 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypercalcemia 2 98.72 Very High Very High Very High
Arthritis 46 91.80 High High
INFLAMMATION 18 53.72 Quite High
Disease 12 51.56 Quite High
Rheumatoid Arthritis 36 44.96 Quite Low
Apoptosis 6 20.56 Low Low
Death 1 10.92 Low Low
Osteoarthritis 11 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 7 5.00 Very Low Very Low Very Low
Necrosis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of the present study was to investigate the effect of a selective Src family kinase inhibitor, 4-amino-5-(4-chlorophenyl)-(t-butyl)pyrazolo[3,4-D]pyrimidine (PP2), on the rewarding effect and hyperlocomotion induced by morphine.
Spec (investigate) Regulation (effect) of Src family kinase associated with morphine
1) Confidence 0.30 Published 2006 Journal Neuroreport Section Abstract Doc Link 16407755 Disease Relevance 0 Pain Relevance 0.47
Src tyrosine kinase function (and two of its targets, Ras and Cbl) are required for bone resorption by osteoclasts [28-30].
Regulation (targets) of Src tyrosine kinase in osteoclasts associated with hypercalcemia
2) Confidence 0.07 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC416442 Disease Relevance 0.42 Pain Relevance 0.12

General Comments

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