INT132846

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Context Info
Confidence 0.69
First Reported 2005
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 10.28
Pain Relevance 2.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Tnfsf11) extracellular space (Tnfsf11) extracellular region (Tnfsf11)
plasma membrane (Tnfsf11) intracellular (Tnfsf11) cytoplasm (Tnfsf11)
Anatomy Link Frequency
osteoclast 4
osteoblasts 3
T cells 3
stromal cells 2
lymphocytes 2
Tnfsf11 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 120 100.00 Very High Very High Very High
rheumatoid arthritis 47 98.50 Very High Very High Very High
Serotonin 16 98.26 Very High Very High Very High
metalloproteinase 8 95.84 Very High Very High Very High
fluoxetine 7 95.64 Very High Very High Very High
Arthritis 55 95.12 Very High Very High Very High
antagonist 40 93.72 High High
Inflammation 80 85.72 High High
chemokine 15 78.72 Quite High
ketamine 5 62.88 Quite High
Disease Link Frequency Relevance Heat
Cancer 237 99.86 Very High Very High Very High
Osteoporosis 164 99.52 Very High Very High Very High
Hypercalcemia 244 99.40 Very High Very High Very High
Rheumatoid Arthritis 47 98.50 Very High Very High Very High
Atherosclerosis 41 97.40 Very High Very High Very High
Metastasis 96 96.92 Very High Very High Very High
Arthritis 64 95.12 Very High Very High Very High
Calcification 118 94.48 High High
Rupture 22 93.80 High High
Disease 56 91.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B ligand (RANKL)/receptor activator of nuclear factor (NF)?
Localization (factor) of RANKL
1) Confidence 0.69 Published 2007 Journal Clinical and Developmental Immunology Section Abstract Doc Link PMC2248226 Disease Relevance 0.82 Pain Relevance 0.12
However, even this is difficult to reconcile since T lymphocytes have been reported to secrete cytokines with osteoclastogenic activities such as RANKL, TNF?
Localization (secrete) of RANKL in T lymphocytes associated with cytokine
2) Confidence 0.66 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1899087 Disease Relevance 0.16 Pain Relevance 0.10
It is currently difficult to have a clear opinion on the precise role of lymphocytes in bone homeostasis, since lymphocytes secrete RANKL, TNF?
Localization (secrete) of RANKL in lymphocytes
3) Confidence 0.66 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1899087 Disease Relevance 0.23 Pain Relevance 0.04
Unlike for T cells, however, there is no unequivocal evidence to date that 'soluble RANKL' in myeloma is either naturally secreted or cleaved from the cell surface by a proteinase.
Localization (secreted) of RANKL in T cells
4) Confidence 0.66 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1924519 Disease Relevance 0.80 Pain Relevance 0.04
OPG detected in human blood stream (mainly released from endothelial cells) are
Localization (released) of OPG in endothelial cells
5) Confidence 0.65 Published 2007 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2248226 Disease Relevance 1.11 Pain Relevance 0.03
MEM in the presence of M-CSF and RANKL.
Localization (presence) of RANKL
6) Confidence 0.61 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1899087 Disease Relevance 0 Pain Relevance 0.09
So, in the presence of M-CSF and RANKL as well as lymphocytes, spleen cells from K?
Localization (presence) of RANKL in spleen
7) Confidence 0.61 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1899087 Disease Relevance 0 Pain Relevance 0
Unlike for T cells, however, there is no unequivocal evidence to date that 'soluble RANKL' in myeloma is either naturally secreted or cleaved from the cell surface by a proteinase.
Localization (secreted) of RANKL in T cells
8) Confidence 0.61 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1924519 Disease Relevance 0.80 Pain Relevance 0.04
T-cell activation in RA patients may lead to osteoclastogenesis within the synovium, probably via RANKL secretion by activated T cells in an environment conducive to osteoclast differentiation from synovial macrophages.
Localization (secretion) of RANKL in osteoclast associated with rheumatoid arthritis
9) Confidence 0.54 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257432 Disease Relevance 0.60 Pain Relevance 0.28
Serotonin increased osteoprotegerin (OPG) and decreased receptor activator of NF-kappaB ligand (RANKL) secretion from osteoblasts, suggesting a role in osteoblast-induced inhibition of osteoclast differentiation, whereas fluoxetine had the opposite effect.
Localization (secretion) of RANKL in osteoclast associated with osteoporosis, serotonin and fluoxetine
10) Confidence 0.52 Published 2006 Journal J. Cell. Biochem. Section Abstract Doc Link 16408289 Disease Relevance 0.15 Pain Relevance 0.99
IL-1 is further involved in bone metabolism as an osteoblast activator: osteoblasts secrete RANKL which promotes survival and differentiation of the osteoclast precursors to mature osteoclasts through RANK.
Localization (secrete) of RANKL in osteoblasts associated with osteoporosis
11) Confidence 0.41 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1308846 Disease Relevance 0.69 Pain Relevance 0.27
The RANK–RANKL pathway is inhibited by a soluble competitor of RANKL, osteoprotegerin (OPG), which is secreted by the same cell population (osteoblasts and stromal cells) in response to different stimuli (estradiol, TGF-?
Localization (secreted) of RANKL in osteoblasts
12) Confidence 0.35 Published 2008 Journal J Orthop Traumatol Section Body Doc Link PMC2657328 Disease Relevance 0.39 Pain Relevance 0.13
The RANK–RANKL pathway is inhibited by a soluble competitor of RANKL, osteoprotegerin (OPG), which is secreted by the same cell population (osteoblasts and stromal cells) in response to different stimuli (estradiol, TGF-?
Localization (secreted) of OPG in osteoblasts
13) Confidence 0.31 Published 2008 Journal J Orthop Traumatol Section Body Doc Link PMC2657328 Disease Relevance 0.39 Pain Relevance 0.12
So, in the presence of M-CSF and RANKL as well as lymphocytes, spleen cells from K?
Localization (presence) of RANKL in lymphocytes
14) Confidence 0.21 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1899087 Disease Relevance 0 Pain Relevance 0
Cancer cells release paradigmatic “osteolytic” cytokines, such as parathyroid hormone-related protein (PTHrP), receptor activator of NF-B ligand (RANKL), interleukin-8 (IL-8) and colony stimulating factor-1 (CSF-1), directly or indirectly responsible for the increase in osteoclast recruitment, activity and survival.
Localization (release) of RANKL in osteoclast associated with cancer and cytokine
15) Confidence 0.18 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020964 Disease Relevance 1.79 Pain Relevance 0.20
This hypothesis postulates that factors such as PTHrP [26], RANKL [27] and IL-8 [28] are secreted by cancer cells and stimulate osteoclast recruitment and activity.
Localization (secreted) of RANKL in osteoclast associated with cancer
16) Confidence 0.18 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020964 Disease Relevance 1.58 Pain Relevance 0.09
The RANK–RANKL pathway is inhibited by a soluble competitor of RANKL, osteoprotegerin (OPG), which is secreted by the same cell population (osteoblasts and stromal cells) in response to different stimuli (estradiol, TGF-?
Localization (secreted) of RANKL in stromal cells
17) Confidence 0.12 Published 2008 Journal J Orthop Traumatol Section Body Doc Link PMC2657328 Disease Relevance 0.39 Pain Relevance 0.13
The RANK–RANKL pathway is inhibited by a soluble competitor of RANKL, osteoprotegerin (OPG), which is secreted by the same cell population (osteoblasts and stromal cells) in response to different stimuli (estradiol, TGF-?
Localization (secreted) of OPG in stromal cells
18) Confidence 0.10 Published 2008 Journal J Orthop Traumatol Section Body Doc Link PMC2657328 Disease Relevance 0.39 Pain Relevance 0.12

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