INT132847

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Context Info
Confidence 0.32
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.16
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Tnfsf11) extracellular space (Tnfsf11) extracellular region (Tnfsf11)
plasma membrane (Tnfsf11) intracellular (Tnfsf11) cytoplasm (Tnfsf11)
Anatomy Link Frequency
osteoclast 2
Tnfsf11 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 16 99.26 Very High Very High Very High
antagonist 1 95.72 Very High Very High Very High
fluoxetine 7 95.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Osteoporosis 1 98.40 Very High Very High Very High
Hypercalcemia 1 57.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serotonin increased osteoprotegerin (OPG) and decreased receptor activator of NF-kappaB ligand (RANKL) secretion from osteoblasts, suggesting a role in osteoblast-induced inhibition of osteoclast differentiation, whereas fluoxetine had the opposite effect.
Negative_regulation (decreased) of Localization (secretion) of RANKL in osteoclast associated with osteoporosis, serotonin and fluoxetine
1) Confidence 0.32 Published 2006 Journal J. Cell. Biochem. Section Abstract Doc Link 16408289 Disease Relevance 0.16 Pain Relevance 1.01

General Comments

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